Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 888033..888509 Replicon chromosome
Accession NZ_CP013619
Organism Staphylococcus aureus strain RIVM1607

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AUC49_RS04260 Protein ID WP_000052076.1
Coordinates 888033..888221 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AUC49_RS04265 Protein ID WP_001059690.1
Coordinates 888249..888509 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUC49_RS04230 884062..884544 + 483 WP_000824489.1 hypothetical protein -
AUC49_RS04235 884885..885571 + 687 WP_001574556.1 thermonuclease family protein -
AUC49_RS04240 885928..886128 + 201 WP_001059082.1 cold-shock protein -
AUC49_RS04245 886625..886843 - 219 WP_000005881.1 hypothetical protein -
AUC49_RS04250 886904..887188 - 285 WP_001004403.1 hypothetical protein -
AUC49_RS04255 887276..887845 - 570 WP_001106655.1 hypothetical protein -
AUC49_RS04260 888033..888221 - 189 WP_000052076.1 hypothetical protein Toxin
AUC49_RS04265 888249..888509 - 261 WP_001059690.1 hypothetical protein Antitoxin
AUC49_RS04270 888851..889054 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AUC49_RS04275 889051..889287 - 237 WP_000368687.1 hypothetical protein -
AUC49_RS04280 889512..890093 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
AUC49_RS04285 890166..890783 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
AUC49_RS04290 890932..891426 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
AUC49_RS04295 891825..892247 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
AUC49_RS04300 892395..893111 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T59029 WP_000052076.1 NZ_CP013619:c888221-888033 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T59029 NZ_CP013619:c888221-888033 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT59029 WP_001059690.1 NZ_CP013619:c888509-888249 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT59029 NZ_CP013619:c888509-888249 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References