Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1572241..1573038 Replicon chromosome
Accession NZ_CP013616
Organism Staphylococcus aureus strain RIVM1295

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag AUC48_RS07660 Protein ID WP_000525004.1
Coordinates 1572577..1573038 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag AUC48_RS07655 Protein ID WP_001260487.1
Coordinates 1572241..1572564 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUC48_RS07585 1567667..1568203 - 537 WP_000999048.1 host-nuclease inhibitor Gam family protein -
AUC48_RS07590 1568216..1568476 - 261 WP_000291481.1 DUF1108 family protein -
AUC48_RS07595 1568481..1568783 - 303 WP_031838380.1 DUF2482 family protein -
AUC48_RS07600 1568848..1569162 - 315 WP_031838381.1 hypothetical protein -
AUC48_RS07605 1569167..1569337 - 171 WP_031838382.1 DUF1270 domain-containing protein -
AUC48_RS07610 1569350..1569613 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
AUC48_RS07615 1569638..1569853 - 216 WP_001097552.1 hypothetical protein -
AUC48_RS07620 1569908..1570273 + 366 WP_016170627.1 hypothetical protein -
AUC48_RS07625 1570242..1570487 - 246 WP_001025401.1 DUF2829 domain-containing protein -
AUC48_RS07630 1570543..1570752 + 210 WP_000642492.1 hypothetical protein -
AUC48_RS07635 1570742..1570885 - 144 WP_000939498.1 hypothetical protein -
AUC48_RS07640 1570956..1571168 + 213 WP_000362644.1 hypothetical protein -
AUC48_RS14810 1571209..1571358 - 150 WP_000771849.1 hypothetical protein -
AUC48_RS07645 1571373..1571816 - 444 WP_000435362.1 hypothetical protein -
AUC48_RS07650 1571829..1572077 - 249 WP_000272859.1 helix-turn-helix domain-containing protein -
AUC48_RS07655 1572241..1572564 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
AUC48_RS07660 1572577..1573038 + 462 WP_000525004.1 hypothetical protein Toxin
AUC48_RS07665 1573056..1573640 + 585 WP_000825948.1 hypothetical protein -
AUC48_RS07670 1573870..1574016 + 147 WP_001795334.1 hypothetical protein -
AUC48_RS07675 1574013..1574627 - 615 WP_000191464.1 hypothetical protein -
AUC48_RS07680 1574753..1575958 + 1206 WP_031585161.1 site-specific integrase -
AUC48_RS07685 1576001..1578028 - 2028 WP_060578201.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1530962..1593589 62627


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T59021 WP_000525004.1 NZ_CP013616:1572577-1573038 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T59021 NZ_CP013616:1572577-1573038 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT59021 WP_001260487.1 NZ_CP013616:1572241-1572564 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT59021 NZ_CP013616:1572241-1572564 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References