Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 860582..861058 Replicon chromosome
Accession NZ_CP013616
Organism Staphylococcus aureus strain RIVM1295

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AUC48_RS04095 Protein ID WP_000052076.1
Coordinates 860582..860770 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AUC48_RS04100 Protein ID WP_001059690.1
Coordinates 860798..861058 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUC48_RS04065 856611..857093 + 483 WP_000824489.1 hypothetical protein -
AUC48_RS04070 857434..858120 + 687 WP_001574556.1 thermonuclease family protein -
AUC48_RS04075 858477..858677 + 201 WP_001059082.1 cold-shock protein -
AUC48_RS04080 859174..859392 - 219 WP_000005881.1 hypothetical protein -
AUC48_RS04085 859453..859737 - 285 WP_001004403.1 hypothetical protein -
AUC48_RS04090 859825..860394 - 570 WP_001106655.1 hypothetical protein -
AUC48_RS04095 860582..860770 - 189 WP_000052076.1 hypothetical protein Toxin
AUC48_RS04100 860798..861058 - 261 WP_001059690.1 hypothetical protein Antitoxin
AUC48_RS04105 861400..861603 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AUC48_RS04110 861600..861836 - 237 WP_060578189.1 hypothetical protein -
AUC48_RS04115 862061..862642 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
AUC48_RS04120 862715..863332 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
AUC48_RS04125 863481..863975 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
AUC48_RS04130 864374..864796 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
AUC48_RS04135 864944..865660 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T59016 WP_000052076.1 NZ_CP013616:c860770-860582 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T59016 NZ_CP013616:c860770-860582 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT59016 WP_001059690.1 NZ_CP013616:c861058-860798 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT59016 NZ_CP013616:c861058-860798 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References