Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 120258..120842 Replicon chromosome
Accession NZ_CP013601
Organism Rhizobium sp. N731

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AMK02_RS00570 Protein ID WP_064800213.1
Coordinates 120258..120440 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AMK02_RS00575 Protein ID WP_064800214.1
Coordinates 120447..120842 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMK02_RS00540 115568..116041 - 474 WP_064800209.1 hypothetical protein -
AMK02_RS00545 116219..116854 + 636 WP_064805816.1 trimeric intracellular cation channel family protein -
AMK02_RS00550 116870..117289 - 420 WP_064800210.1 transcriptional repressor -
AMK02_RS00555 117592..118107 + 516 WP_020920068.1 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA -
AMK02_RS00560 118153..119385 + 1233 WP_064800211.1 beta-ketoacyl-ACP synthase I -
AMK02_RS00565 119390..120196 + 807 WP_064800212.1 enoyl-ACP reductase FabI -
AMK02_RS00570 120258..120440 + 183 WP_064800213.1 type II toxin-antitoxin system HicA family toxin Toxin
AMK02_RS00575 120447..120842 + 396 WP_064800214.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AMK02_RS00580 120846..121862 - 1017 WP_064800215.1 class I SAM-dependent methyltransferase -
AMK02_RS00585 121938..124076 - 2139 WP_011423507.1 polyribonucleotide nucleotidyltransferase -
AMK02_RS00590 124427..124696 - 270 WP_009997779.1 30S ribosomal protein S15 -
AMK02_RS00595 124846..125694 - 849 WP_064800216.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6738.86 Da        Isoelectric Point: 11.9739

>T59008 WP_064800213.1 NZ_CP013601:120258-120440 [Rhizobium sp. N731]
IRTNQKIIARLKREGFEVVSIKGSHHKLRRGNQTVIVSHPRKDLPIGTALAIAKQAGWNE

Download         Length: 183 bp

>T59008 NZ_CP013601:120258-120440 [Rhizobium sp. N731]
ATCCGGACGAACCAGAAGATTATCGCCAGGCTGAAGCGGGAGGGCTTCGAAGTGGTTTCAATCAAGGGCTCGCACCACAA
GCTTCGAAGAGGCAATCAGACCGTTATCGTTTCGCATCCCAGGAAGGATCTGCCGATCGGCACTGCGCTTGCGATTGCGA
AGCAGGCCGGCTGGAATGAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14320.11 Da        Isoelectric Point: 4.5478

>AT59008 WP_064800214.1 NZ_CP013601:120447-120842 [Rhizobium sp. N731]
IKYFIALVHKDKNSAFGVSFPDLPSVFSAAGEEEDLTANAIDALRLWAEDETLPVPSSYDEISSRPDIREQLAAGAFLTR
VPFIEDTTRTVRANVTFDKGMLDAIDKAAKERGLTRSAFLASAARKEIEAA

Download         Length: 396 bp

>AT59008 NZ_CP013601:120447-120842 [Rhizobium sp. N731]
ATAAAATATTTCATTGCGCTCGTACATAAGGACAAGAATAGCGCCTTCGGCGTCAGCTTTCCGGATCTGCCGTCGGTATT
CTCCGCGGCAGGTGAGGAAGAGGATCTTACCGCAAACGCCATCGACGCACTTCGTCTCTGGGCGGAGGATGAAACCTTGC
CGGTACCGTCCTCCTACGACGAGATCAGTTCGAGACCGGATATCCGCGAGCAGCTGGCTGCAGGCGCTTTTCTGACGCGG
GTTCCCTTTATCGAAGATACGACGCGCACCGTTAGAGCCAATGTCACTTTCGACAAAGGCATGCTTGACGCGATCGATAA
GGCCGCAAAGGAGCGCGGCCTTACCCGTTCGGCTTTCCTTGCAAGCGCTGCCCGCAAGGAGATCGAGGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References