Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1708928..1709523 Replicon chromosome
Accession NZ_CP013580
Organism Rhizobium phaseoli strain N261

Toxin (Protein)


Gene name vapC Uniprot ID A0A1W6GGE4
Locus tag AMC79_RS08305 Protein ID WP_064817946.1
Coordinates 1708928..1709317 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1W6GGF9
Locus tag AMC79_RS08310 Protein ID WP_064817947.1
Coordinates 1709314..1709523 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMC79_RS08285 1704152..1704772 - 621 WP_064817942.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
AMC79_RS08290 1704818..1706107 - 1290 WP_064817943.1 dihydroorotase -
AMC79_RS08295 1706104..1707060 - 957 WP_064817944.1 aspartate carbamoyltransferase catalytic subunit -
AMC79_RS08300 1707239..1708897 + 1659 WP_064817945.1 acyl-CoA dehydrogenase family protein -
AMC79_RS08305 1708928..1709317 - 390 WP_064817946.1 PIN domain nuclease Toxin
AMC79_RS08310 1709314..1709523 - 210 WP_064817947.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AMC79_RS08315 1709667..1712558 - 2892 WP_064817948.1 ribonuclease E/G -
AMC79_RS08320 1713181..1714455 + 1275 WP_037138152.1 N-acetylmuramoyl-L-alanine amidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14778.09 Da        Isoelectric Point: 6.2388

>T58979 WP_064817946.1 NZ_CP013580:c1709317-1708928 [Rhizobium phaseoli]
VIVVDSSVWIAHLRGIESEARRRLQNIEDPLEILVGDVILLEVLQGARNERHAATIEASLRQFTLRPMLDDKLAVRAARN
YRLLRERGITVRKTIDLIIGTFCIQEGYSLLHDDRDFDPMAEYLGLRIA

Download         Length: 390 bp

>T58979 NZ_CP013580:c1709317-1708928 [Rhizobium phaseoli]
GTGATCGTCGTCGACAGTTCGGTCTGGATCGCGCATCTACGCGGGATAGAAAGTGAGGCCAGACGACGTCTGCAGAATAT
CGAGGATCCGCTCGAGATTCTTGTTGGTGACGTTATCCTTTTGGAAGTGCTTCAGGGCGCGCGCAACGAACGCCATGCAG
CCACCATCGAAGCGAGCTTGCGCCAATTCACTCTCCGCCCGATGCTTGACGACAAACTCGCTGTTAGGGCAGCTCGCAAC
TACCGCCTGTTACGGGAACGCGGCATCACAGTGCGCAAGACCATCGACCTGATCATCGGCACATTCTGCATTCAGGAAGG
CTATTCGCTCTTACACGATGATCGGGATTTCGATCCGATGGCCGAGTATCTCGGCCTCAGGATCGCCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7720.65 Da        Isoelectric Point: 5.7881

>AT58979 WP_064817947.1 NZ_CP013580:c1709523-1709314 [Rhizobium phaseoli]
MRTNIDIDDALLDAAMTATGLTTKKATIEQALRNLVDRHRRKNAIANLSGIGWEGDLDEMRRGRPDDNQ

Download         Length: 210 bp

>AT58979 NZ_CP013580:c1709523-1709314 [Rhizobium phaseoli]
ATGCGGACGAATATAGATATCGATGATGCGTTACTCGACGCAGCAATGACCGCCACCGGATTGACGACGAAAAAAGCCAC
CATCGAACAGGCCCTGCGAAACCTTGTCGACAGGCACCGCCGGAAAAACGCGATAGCAAATCTCTCAGGAATCGGCTGGG
AAGGGGATCTGGACGAGATGCGTCGCGGTCGTCCGGACGATAATCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W6GGE4

Antitoxin

Source ID Structure
AlphaFold DB A0A1W6GGF9

References