Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1173869..1174530 Replicon chromosome
Accession NZ_CP013574
Organism Rhizobium phaseoli strain N671

Toxin (Protein)


Gene name vapB Uniprot ID B3PTF5
Locus tag AMC80_RS05755 Protein ID WP_010025678.1
Coordinates 1173869..1174276 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B3PTF6
Locus tag AMC80_RS05760 Protein ID WP_004676069.1
Coordinates 1174276..1174530 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMC80_RS05730 1168991..1170202 - 1212 WP_012483084.1 MFS transporter -
AMC80_RS05735 1170692..1171699 + 1008 WP_012483085.1 asparaginase -
AMC80_RS05740 1171700..1172455 - 756 WP_041683574.1 DeoR/GlpR family DNA-binding transcription regulator -
AMC80_RS05745 1172597..1172953 + 357 WP_010007611.1 hypothetical protein -
AMC80_RS05750 1173203..1173823 + 621 WP_012483086.1 glutathione S-transferase -
AMC80_RS05755 1173869..1174276 - 408 WP_010025678.1 type II toxin-antitoxin system VapC family toxin Toxin
AMC80_RS05760 1174276..1174530 - 255 WP_004676069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AMC80_RS05765 1174634..1175611 - 978 WP_064824980.1 phosphodiester glycosidase family protein -
AMC80_RS05775 1176084..1176980 + 897 WP_004676067.1 LysR family transcriptional regulator -
AMC80_RS05780 1177087..1177752 - 666 WP_064825820.1 glutathione S-transferase family protein -
AMC80_RS05785 1177983..1178222 + 240 WP_012483092.1 hypothetical protein -
AMC80_RS05790 1178241..1178705 + 465 WP_012483093.1 YbhB/YbcL family Raf kinase inhibitor-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-62)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14756.97 Da        Isoelectric Point: 6.9902

>T58968 WP_010025678.1 NZ_CP013574:c1174276-1173869 [Rhizobium phaseoli]
MYLVDTNIVSEARRGTPQAVTWLRSVDPLSIHLSALTLGEIMRGIALKQKSDPKAAGHLAEWLRKLRHDHGARILPVTDQ
IAVEWGRIAAIRPRGDIDGLIAATAIVHDLIVVTRNVGDFNDTGVSVIDPWEPSA

Download         Length: 408 bp

>T58968 NZ_CP013574:c1174276-1173869 [Rhizobium phaseoli]
ATGTATCTGGTTGATACGAATATCGTCTCGGAGGCGCGGCGCGGCACGCCGCAGGCGGTTACCTGGCTGCGCTCCGTCGA
CCCGCTGAGCATCCATCTGAGCGCCCTGACCCTTGGCGAGATCATGCGCGGCATTGCCCTCAAACAGAAGTCGGATCCGA
AGGCCGCAGGCCACCTCGCCGAGTGGCTGCGCAAGCTGCGCCATGATCACGGCGCCCGCATCCTGCCGGTAACAGATCAG
ATCGCCGTGGAATGGGGCCGAATCGCCGCGATCCGGCCGCGCGGCGACATCGATGGACTGATCGCCGCGACCGCCATCGT
CCATGATCTGATCGTCGTCACCCGCAATGTCGGCGACTTCAATGACACCGGCGTATCGGTGATCGACCCTTGGGAACCCT
CGGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9325.40 Da        Isoelectric Point: 4.7730

>AT58968 WP_004676069.1 NZ_CP013574:c1174530-1174276 [Rhizobium phaseoli]
MEWQLQDAKNQFSKVVQRARDEGPQVVTLRGERTAVVLSARDYDALRAGRPTLVDDLLGGPAWDDELADAVEARAKNPSR
SVTF

Download         Length: 255 bp

>AT58968 NZ_CP013574:c1174530-1174276 [Rhizobium phaseoli]
ATGGAATGGCAGTTGCAGGACGCCAAGAATCAGTTCTCGAAGGTAGTTCAGAGGGCGCGAGATGAGGGGCCGCAGGTGGT
GACGTTGCGCGGAGAGCGGACGGCTGTCGTCTTATCCGCCCGCGATTACGACGCCCTGCGCGCCGGCCGCCCGACGCTCG
TCGACGATCTGCTGGGCGGTCCTGCCTGGGACGACGAGCTTGCCGATGCGGTGGAAGCTCGGGCCAAGAACCCAAGCCGT
AGCGTGACCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192T5A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2U3D218

References