Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1225055..1225716 Replicon chromosome
Accession NZ_CP013527
Organism Rhizobium phaseoli strain R723

Toxin (Protein)


Gene name vapB Uniprot ID F2ACM9
Locus tag AMC89_RS05930 Protein ID WP_004676070.1
Coordinates 1225055..1225462 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B3PTF6
Locus tag AMC89_RS05935 Protein ID WP_004676069.1
Coordinates 1225462..1225716 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMC89_RS05905 1220183..1221391 - 1209 Protein_1158 MFS transporter -
AMC89_RS05910 1221880..1222887 + 1008 WP_064817718.1 asparaginase -
AMC89_RS05915 1222888..1223643 - 756 WP_064817719.1 DeoR/GlpR family DNA-binding transcription regulator -
AMC89_RS05920 1223785..1224141 + 357 WP_064817720.1 hypothetical protein -
AMC89_RS05925 1224389..1225009 + 621 WP_004676071.1 glutathione S-transferase -
AMC89_RS05930 1225055..1225462 - 408 WP_004676070.1 type II toxin-antitoxin system VapC family toxin Toxin
AMC89_RS05935 1225462..1225716 - 255 WP_004676069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AMC89_RS05940 1225820..1226797 - 978 WP_037137484.1 phosphodiester glycosidase family protein -
AMC89_RS05945 1226946..1227140 - 195 WP_064817721.1 hypothetical protein -
AMC89_RS05950 1227275..1228171 + 897 WP_037137488.1 LysR family transcriptional regulator -
AMC89_RS05955 1228279..1228944 - 666 WP_037137965.1 glutathione S-transferase family protein -
AMC89_RS05960 1229174..1229413 + 240 WP_037137489.1 hypothetical protein -
AMC89_RS05965 1229432..1229896 + 465 WP_037137491.1 YbhB/YbcL family Raf kinase inhibitor-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-62)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14732.90 Da        Isoelectric Point: 6.9902

>T58890 WP_004676070.1 NZ_CP013527:c1225462-1225055 [Rhizobium phaseoli]
MYLVDTNIVSEARRGTPQAVTWLRSVDPLSIHLSALTLGEIMRGIALKQKSDPKAAGHLAEWLRKLRHDHGARILPVTDQ
IAVEWGRIAAIRPRGDIDGLIAATAIVHDLIVVTRNVGDFNDTGASVIDPWETSA

Download         Length: 408 bp

>T58890 NZ_CP013527:c1225462-1225055 [Rhizobium phaseoli]
ATGTATCTGGTTGATACGAATATCGTCTCGGAGGCGCGGCGCGGCACGCCGCAGGCGGTTACCTGGCTGCGCTCCGTCGA
CCCGCTGAGCATCCATCTGAGCGCCCTGACCCTTGGCGAGATCATGCGCGGCATTGCCCTCAAACAGAAGTCGGATCCGA
AGGCCGCAGGCCACCTCGCCGAGTGGCTGCGCAAGCTGCGCCATGATCACGGCGCCCGCATCCTGCCGGTAACAGATCAG
ATCGCCGTGGAATGGGGCCGAATCGCCGCGATCCGGCCGCGCGGCGACATCGATGGACTGATCGCCGCGACCGCCATCGT
CCATGATCTGATCGTCGTCACCCGCAATGTCGGCGACTTCAATGACACGGGCGCATCGGTGATCGATCCCTGGGAGACCT
CGGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9325.40 Da        Isoelectric Point: 4.7730

>AT58890 WP_004676069.1 NZ_CP013527:c1225716-1225462 [Rhizobium phaseoli]
MEWQLQDAKNQFSKVVQRARDEGPQVVTLRGERTAVVLSARDYDALRAGRPTLVDDLLGGPAWDDELADAVEARAKNPSR
SVTF

Download         Length: 255 bp

>AT58890 NZ_CP013527:c1225716-1225462 [Rhizobium phaseoli]
ATGGAATGGCAGTTGCAGGACGCCAAGAATCAGTTCTCGAAGGTAGTTCAGAGGGCGCGAGATGAGGGGCCGCAGGTGGT
GACGTTGCGCGGAGAGCGGACGGCTGTCGTCTTATCCGCCCGCGATTACGACGCCCTGCGCGCCGGCCGCCCGACGCTCG
TCGACGATCTGCTGGGCGGTCCTGCCTGGGACGACGAGCTTGCCGATGCGGTGGAAGCTCGGGCCAAGAACCCAAGCCGT
AGCGTGACCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F2ACM9

Antitoxin

Source ID Structure
AlphaFold DB A0A2U3D218

References