Detailed information of TA system TA058888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 247558..248102
• Replicon: chromosome
• Accession: NZ_CP013527
• Organism: Rhizobium phaseoli strain R723

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AMC89_RS01155
• Protein ID: WP_064817240.1
• Coordinates: 247812..248102 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F2A8A7
• Locus tag: AMC89_RS01150
• Protein ID: WP_004673546.1
• Coordinates: 247558..247809 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AMC89_RS01125	243543..244502	+	960	WP_064817237.1	glyoxylate/hydroxypyruvate reductase A	-
AMC89_RS01130	244698..245054	+	357	WP_064817238.1	hypothetical protein	-
AMC89_RS01135	245223..246527	+	1305	WP_004673542.1	nicotinate phosphoribosyltransferase	-
AMC89_RS01140	246524..246811	-	288	WP_081279319.1	hypothetical protein	-
AMC89_RS01145	247142..247351	-	210	WP_010023871.1	KTSC domain-containing protein	-
AMC89_RS01150	247558..247809	+	252	WP_004673546.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
AMC89_RS01155	247812..248102	+	291	WP_064817240.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AMC89_RS01165	248450..248767	+	318	WP_004673550.1	hypothetical protein	-
AMC89_RS01170	249095..250087	+	993	WP_004673552.1	BMP family ABC transporter substrate-binding protein	-
AMC89_RS01175	250176..251687	+	1512	WP_037115036.1	ABC transporter ATP-binding protein	-
AMC89_RS01180	251695..252798	+	1104	WP_004673554.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11061.58 Da
• Isoelectric Point: 6.3748

>T58888 WP_064817240.1 NZ_CP013527:247812-248102 [Rhizobium phaseoli]
MGFRLTQEAEEDIIGIAETGIRLFGSAHARRYHDELYAIFDLIAANPRMARERDEISPPMRIHPFKAHLVVYTIVEGDHV
LIVRIRHGHEDWSSQA

Nucleotide

• Length: 291 bp

>T58888 NZ_CP013527:247812-248102 [Rhizobium phaseoli]
ATGGGCTTTCGCCTTACGCAAGAAGCGGAAGAGGACATTATCGGCATAGCCGAAACCGGTATTCGCCTGTTTGGCTCAGC
GCACGCTCGGCGCTACCATGATGAACTCTACGCCATTTTTGATCTGATTGCTGCCAATCCCCGTATGGCGCGCGAACGGG
ATGAAATTTCTCCTCCGATGCGCATCCATCCGTTCAAGGCACATCTCGTCGTCTATACGATTGTGGAGGGCGATCATGTT
CTCATTGTCCGTATTCGCCACGGACACGAAGATTGGTCCAGTCAGGCTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9308.43 Da
• Isoelectric Point: 9.6900

>AT58888 WP_004673546.1 NZ_CP013527:247558-247809 [Rhizobium phaseoli]
MATMNVSLPDPMKDWVEAQTKTGRYANASDYVRDLIRKDQERNDKIAAMQRFVDEGLKSGVGSRSKDALFEAARARVESS
RGN

Nucleotide

• Length: 252 bp

>AT58888 NZ_CP013527:247558-247809 [Rhizobium phaseoli]
ATGGCGACCATGAACGTATCCCTGCCCGATCCCATGAAAGATTGGGTGGAAGCGCAAACCAAAACAGGCCGTTATGCCAA
TGCGAGCGATTATGTCCGCGACCTCATCAGGAAAGACCAGGAGCGAAACGATAAGATTGCCGCTATGCAGCGCTTTGTCG
ATGAAGGCTTGAAGAGCGGCGTCGGGTCGCGGTCGAAGGACGCACTGTTTGAGGCGGCGCGGGCGCGCGTGGAAAGCTCT
CGCGGCAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0M3GP98