Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1191357..1192018 Replicon chromosome
Accession NZ_CP013522
Organism Rhizobium phaseoli strain R744

Toxin (Protein)


Gene name vapB Uniprot ID B3PTF5
Locus tag AMC90_RS05735 Protein ID WP_010025678.1
Coordinates 1191357..1191764 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B3PTF6
Locus tag AMC90_RS05740 Protein ID WP_004676069.1
Coordinates 1191764..1192018 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMC90_RS05710 1186479..1187690 - 1212 WP_012483084.1 MFS transporter -
AMC90_RS05715 1188180..1189187 + 1008 WP_012483085.1 asparaginase -
AMC90_RS05720 1189188..1189943 - 756 WP_041683574.1 DeoR/GlpR family DNA-binding transcription regulator -
AMC90_RS05725 1190085..1190441 + 357 WP_010007611.1 hypothetical protein -
AMC90_RS05730 1190691..1191311 + 621 WP_012483086.1 glutathione S-transferase -
AMC90_RS05735 1191357..1191764 - 408 WP_010025678.1 type II toxin-antitoxin system VapC family toxin Toxin
AMC90_RS05740 1191764..1192018 - 255 WP_004676069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AMC90_RS05745 1192122..1193099 - 978 WP_064824980.1 phosphodiester glycosidase family protein -
AMC90_RS33100 1193089..1193541 + 453 WP_190299945.1 hypothetical protein -
AMC90_RS05755 1193573..1194469 + 897 WP_004676067.1 LysR family transcriptional regulator -
AMC90_RS05760 1194577..1195150 - 574 Protein_1141 glutathione S-transferase -
AMC90_RS05765 1195381..1195620 + 240 WP_064842502.1 hypothetical protein -
AMC90_RS05770 1195639..1196103 + 465 WP_012483093.1 YbhB/YbcL family Raf kinase inhibitor-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-62)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14756.97 Da        Isoelectric Point: 6.9902

>T58882 WP_010025678.1 NZ_CP013522:c1191764-1191357 [Rhizobium phaseoli]
MYLVDTNIVSEARRGTPQAVTWLRSVDPLSIHLSALTLGEIMRGIALKQKSDPKAAGHLAEWLRKLRHDHGARILPVTDQ
IAVEWGRIAAIRPRGDIDGLIAATAIVHDLIVVTRNVGDFNDTGVSVIDPWEPSA

Download         Length: 408 bp

>T58882 NZ_CP013522:c1191764-1191357 [Rhizobium phaseoli]
ATGTATCTGGTTGATACGAATATCGTCTCGGAGGCGCGGCGCGGCACGCCGCAGGCGGTTACCTGGCTGCGCTCCGTCGA
CCCGCTGAGCATCCATCTGAGCGCCCTGACCCTTGGCGAGATCATGCGCGGCATTGCCCTCAAACAGAAGTCGGATCCGA
AGGCCGCAGGCCACCTCGCCGAGTGGCTGCGCAAGCTGCGCCATGATCACGGCGCCCGCATCCTGCCGGTAACAGATCAG
ATCGCCGTGGAATGGGGCCGAATCGCCGCGATCCGGCCGCGCGGCGACATCGATGGACTGATCGCCGCGACCGCCATCGT
CCATGATCTGATCGTCGTCACCCGCAATGTCGGCGACTTCAATGACACCGGCGTATCGGTGATCGACCCTTGGGAACCCT
CGGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9325.40 Da        Isoelectric Point: 4.7730

>AT58882 WP_004676069.1 NZ_CP013522:c1192018-1191764 [Rhizobium phaseoli]
MEWQLQDAKNQFSKVVQRARDEGPQVVTLRGERTAVVLSARDYDALRAGRPTLVDDLLGGPAWDDELADAVEARAKNPSR
SVTF

Download         Length: 255 bp

>AT58882 NZ_CP013522:c1192018-1191764 [Rhizobium phaseoli]
ATGGAATGGCAGTTGCAGGACGCCAAGAATCAGTTCTCGAAGGTAGTTCAGAGGGCGCGAGATGAGGGGCCGCAGGTGGT
GACGTTGCGCGGAGAGCGGACGGCTGTCGTCTTATCCGCCCGCGATTACGACGCCCTGCGCGCCGGCCGCCCGACGCTCG
TCGACGATCTGCTGGGCGGTCCTGCCTGGGACGACGAGCTTGCCGATGCGGTGGAAGCTCGGGCCAAGAACCCAAGCCGT
AGCGTGACCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192T5A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2U3D218

References