Detailed information of TA system TA058837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1056552..1057111
• Replicon: chromosome
• Accession: NZ_CP013484
• Organism: Vibrio alginolyticus strain ATCC 33787

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2I3C6F2
• Locus tag: AT730_RS04825
• Protein ID: WP_005377065.1
• Coordinates: 1056833..1057111 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2I3C6F3
• Locus tag: AT730_RS04820
• Protein ID: WP_005487956.1
• Coordinates: 1056552..1056836 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT730_RS04790	1052294..1052633	-	340	Protein_968	hypothetical protein	-
AT730_RS04795	1052785..1053423	-	639	WP_064368554.1	hypothetical protein	-
AT730_RS04800	1053624..1053980	+	357	WP_064368555.1	hypothetical protein	-
AT730_RS04805	1054202..1055173	+	972	WP_050550131.1	IS30 family transposase	-
AT730_RS04810	1055207..1055665	-	459	WP_064368556.1	GNAT family N-acetyltransferase	-
AT730_RS04815	1055781..1056353	-	573	WP_064368557.1	hypothetical protein	-
AT730_RS04820	1056552..1056836	+	285	WP_005487956.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AT730_RS04825	1056833..1057111	+	279	WP_005377065.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
AT730_RS04830	1058209..1058634	-	426	WP_025507144.1	hypothetical protein	-
AT730_RS26525	1058674..1058766	-	93	WP_197649978.1	DUF3265 domain-containing protein	-
AT730_RS04835	1058800..1059201	-	402	WP_017636213.1	HIT family protein	-
AT730_RS04840	1059341..1060066	-	726	WP_064368558.1	hypothetical protein	-
AT730_RS04845	1060203..1060526	-	324	WP_038217934.1	hypothetical protein	-
AT730_RS26530	1060554..1060643	-	90	WP_079858647.1	DUF3265 domain-containing protein	-
AT730_RS04850	1061211..1061660	-	450	WP_064368559.1	hypothetical protein	-
AT730_RS26535	1061699..1061812	-	114	WP_081048918.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	996140..1081072	84932
	-	flank	IS/Tn	-	-	1054241..1055173	932
	-	inside	Integron	-	-	1033521..1079954	46433

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10905.60 Da
• Isoelectric Point: 4.3430

>T58837 WP_005377065.1 NZ_CP013484:1056833-1057111 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T58837 NZ_CP013484:1056833-1057111 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGTA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGAGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11082.40 Da
• Isoelectric Point: 9.2167

>AT58837 WP_005487956.1 NZ_CP013484:1056552-1056836 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT58837 NZ_CP013484:1056552-1056836 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAAATGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Toxin

• AlphaFold DB: A0A2I3C6F2

Antitoxin

• AlphaFold DB: A0A2I3C6F3