Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4277518..4279369 Replicon chromosome
Accession NZ_CP013481
Organism Pandoraea apista strain DSM 16535

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AT395_RS19255 Protein ID WP_053086368.1
Coordinates 4278461..4279369 (-) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AT395_RS19250 Protein ID WP_082117814.1
Coordinates 4277518..4278459 (-) Length 314 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT395_RS19230 4272749..4274245 - 1497 WP_048628958.1 aldehyde dehydrogenase -
AT395_RS19235 4274259..4275077 - 819 WP_042114941.1 aspartate dehydrogenase -
AT395_RS19240 4275070..4276722 - 1653 WP_042114940.1 thiamine pyrophosphate-binding protein -
AT395_RS19245 4276715..4277521 - 807 WP_042114938.1 SDR family oxidoreductase -
AT395_RS19250 4277518..4278459 - 942 WP_082117814.1 IclR family transcriptional regulator Antitoxin
AT395_RS19255 4278461..4279369 - 909 WP_053086368.1 alpha/beta fold hydrolase Toxin
AT395_RS19260 4279469..4280026 - 558 WP_042114937.1 cupin domain-containing protein -
AT395_RS19265 4280068..4280862 - 795 WP_048628957.1 SDR family oxidoreductase -
AT395_RS19270 4280878..4281660 - 783 WP_042114934.1 ABC transporter permease -
AT395_RS19275 4281699..4282472 - 774 WP_082118012.1 ABC transporter ATP-binding protein -
AT395_RS19280 4282874..4283950 - 1077 WP_042118075.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(168-291)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31382.49 Da        Isoelectric Point: 5.9453

>T58812 WP_053086368.1 NZ_CP013481:c4279369-4278461 [Pandoraea apista]
MQAEASLSEVPEDAAVAPLRARLNAFPYRTLATRTGTVGYRCAGARAEGGMPVVMLHGIGSGAASWLAQFEATGLNAELY
AWDAPGYGQTSNVADAEPHADAYADALEAWLDALGLKRVALVGHSLGAIMATKFASRSPQRVSGLFLCSPAGGYGKADPD
VRVSKRDSRLAMLDKLGPAGMARERSDNLVAPNAADLPRSWVKWNMARVHPAGYRQATHLLSNGDVAGELAQYVAANAGP
VAVAVGAQDAITTPAACQTIADVAGVPLQIIEGAGHASYIETPDVLNAALAAWLERIAAGER

Download         Length: 909 bp

>T58812 NZ_CP013481:c4279369-4278461 [Pandoraea apista]
ATGCAAGCCGAAGCCTCACTGTCCGAAGTGCCCGAAGATGCCGCCGTCGCACCGCTGCGCGCGCGTCTGAATGCTTTCCC
GTACCGCACGCTCGCCACGCGTACGGGCACCGTCGGCTATCGCTGCGCTGGCGCGCGTGCCGAGGGTGGCATGCCGGTCG
TGATGCTGCACGGCATTGGGTCCGGCGCGGCGTCATGGCTGGCGCAGTTCGAAGCCACAGGGCTTAACGCCGAGCTTTAC
GCGTGGGACGCCCCGGGCTATGGGCAGACGTCGAACGTCGCCGATGCCGAGCCGCATGCCGATGCTTACGCCGACGCGCT
TGAGGCGTGGCTCGATGCCCTGGGACTCAAGCGTGTCGCTCTCGTTGGCCACTCGCTGGGTGCGATCATGGCGACGAAGT
TTGCGAGCCGCTCCCCGCAGCGTGTGAGTGGACTCTTTCTCTGCTCGCCGGCCGGCGGTTACGGCAAGGCCGATCCGGAC
GTGCGCGTAAGCAAGCGCGATAGCCGTCTGGCGATGCTCGACAAGCTGGGCCCGGCCGGCATGGCCCGCGAGCGCAGCGA
CAATCTCGTCGCGCCGAATGCCGCAGACCTGCCGCGCTCCTGGGTGAAATGGAACATGGCGCGCGTGCATCCCGCCGGAT
ACCGGCAGGCGACGCACCTTCTCTCGAACGGCGACGTCGCCGGCGAGTTGGCGCAATACGTGGCCGCGAACGCCGGGCCG
GTGGCCGTGGCGGTCGGCGCACAGGATGCGATCACGACGCCCGCAGCTTGCCAGACGATTGCCGACGTGGCCGGCGTGCC
ACTGCAGATCATCGAAGGCGCGGGACACGCGTCGTACATCGAAACCCCGGACGTTCTGAACGCCGCGCTCGCGGCGTGGC
TCGAGCGCATCGCGGCAGGAGAGCGCTGA

Antitoxin


Download         Length: 314 a.a.        Molecular weight: 34121.88 Da        Isoelectric Point: 6.3621

>AT58812 WP_082117814.1 NZ_CP013481:c4278459-4277518 [Pandoraea apista]
MAPATPKRAAAAPDAQIEDDKLGLQDTQTDGDELAEGSTSDTRYLVPGLERGLRILTQFSPREAVFSAPELSQRLGIPRT
TVFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQS
VAGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFER
GISVVSAPVRNDAGRICAAITVTIPRANIDSSMLDAGLIGQVREAADALSHRLNYRPGSDRQPTPYMKSLGLK

Download         Length: 942 bp

>AT58812 NZ_CP013481:c4278459-4277518 [Pandoraea apista]
ATGGCACCGGCAACCCCGAAGCGCGCAGCGGCAGCGCCCGACGCGCAGATCGAAGACGACAAGCTCGGTCTTCAGGACAC
CCAGACCGATGGCGACGAACTCGCCGAAGGTTCAACGTCCGACACCCGTTATCTCGTGCCCGGTCTGGAGCGCGGCTTGC
GCATTCTTACGCAGTTCTCGCCGCGCGAGGCCGTATTCAGCGCGCCGGAGTTGTCGCAACGCCTCGGCATTCCGCGTACC
ACCGTTTTCCGTTTGTTGCAGACGCTTGAAGCGATGGGTTTTCTGGAGCGCGCGGGGAGCGAGAAGAATTTCCGTCTGGG
CGTGGCAGTGCTGCGTCTGGGCTTCGAATACCTCAGTTCGCTGGAGTTGACCGATCTGGGGATTCCGATCATCGAACGGC
TGCGCGACGCCACGCAATTGACCTCGCACATCGTGATCCGGGACGGGCGAGACATCGTGTTCGTGGCGAAGGCGCAAAGC
GTTGCCGGCGTTTTCAATTCGATCAAGGTAAACGTCGGCACGCGTCTGCCGGCGCATGCAACGGTGCATGGCCATGTGCT
GATGGGCGACCTGACGCTGGCCGAGCTTCGTGCGCTGTATCCGGAAAAGACGCTGGAAAAATACACGCCGCAAACGCCCG
AGACGCTTGCGGAGTTGTTCGAACGGGTGCGTGAAGACGCCGAGCGCGGTTACGCGGTGTCGGCTTCGTCGTTCGAGCGG
GGCATCAGTGTCGTGAGTGCACCGGTGCGCAACGACGCGGGCCGTATCTGCGCCGCCATCACCGTGACCATTCCGCGCGC
CAACATCGATTCGTCAATGCTCGATGCGGGGCTGATCGGACAGGTGCGCGAGGCGGCCGATGCGCTGTCGCATCGTCTGA
ACTATCGACCGGGCAGCGACCGTCAACCCACCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References