Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2042437..2043095 Replicon chromosome
Accession NZ_CP013481
Organism Pandoraea apista strain DSM 16535

Toxin (Protein)


Gene name hicA Uniprot ID A0A5E5PAN6
Locus tag AT395_RS09470 Protein ID WP_048629124.1
Coordinates 2042916..2043095 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5E5P9T0
Locus tag AT395_RS09465 Protein ID WP_048629123.1
Coordinates 2042437..2042841 (-) Length 135 a.a.

Genomic Context

AT395_RS09415AT395_RS09420AT395_RS09425AT395_RS09430AT395_RS09435AT395_RS09440AT395_RS09445AT395_RS09450AT395_RS09475AT395_RS09455AT395_RS09465AT395_RS09470AT395_RS09485AT395_RS09490AT395_RS09495
Location: 2037836..2038411 (576 bp)
Type: Others
Protein ID: WP_058375181.1
Location: 2038434..2038970 (537 bp)
Type: Others
Protein ID: WP_048629114.1
Location: 2038985..2039278 (294 bp)
Type: Others
Protein ID: WP_048629115.1
Location: 2039334..2039849 (516 bp)
Type: Others
Protein ID: WP_048629116.1
Location: 2039846..2040040 (195 bp)
Type: Others
Protein ID: WP_048629117.1
Location: 2040109..2040351 (243 bp)
Type: Others
Protein ID: WP_124988637.1
Location: 2040362..2040787 (426 bp)
Type: Others
Protein ID: WP_048629119.1
Location: 2040784..2041146 (363 bp)
Type: Others
Protein ID: WP_048629120.1
Location: 2043209..2043838 (630 bp)
Type: Others
Protein ID: WP_048629125.1
Location: 2041246..2042001 (756 bp)
Type: Others
Protein ID: WP_048629121.1
Location: 2042437..2042841 (405 bp)
Type: Antitoxin
Protein ID: WP_048629123.1
Location: 2042916..2043095 (180 bp)
Type: Toxin
Protein ID: WP_048629124.1
Location: 2044153..2045268 (1116 bp)
Type: Others
Protein ID: WP_042115266.1
Location: 2045600..2046319 (720 bp)
Type: Others
Protein ID: WP_094068917.1
Location: 2046354..2046854 (501 bp)
Type: Others
Protein ID: WP_042115270.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AT395_RS094152037836..2038411+576WP_058375181.1DUF4376 domain-containing protein-
AT395_RS094202038434..2038970+537WP_048629114.1glycoside hydrolase family 104 protein-
AT395_RS094252038985..2039278+294WP_048629115.1holin-
AT395_RS094302039334..2039849+516WP_048629116.1hypothetical protein-
AT395_RS094352039846..2040040+195WP_048629117.1hypothetical protein-
AT395_RS094402040109..2040351+243WP_124988637.1hypothetical protein-
AT395_RS094452040362..2040787+426WP_048629119.1hypothetical protein-
AT395_RS094502040784..2041146+363WP_048629120.1DUF1353 domain-containing protein-
AT395_RS094552041246..2042001-756WP_048629121.1SOS response-associated peptidase family protein-
AT395_RS094652042437..2042841-405WP_048629123.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
AT395_RS094702042916..2043095-180WP_048629124.1type II toxin-antitoxin system HicA family toxinToxin
AT395_RS094752043209..2043838+630WP_048629125.1SOS response-associated peptidase family protein-
AT395_RS094852044153..2045268-1116WP_042115266.1YeeE/YedE family protein-
AT395_RS094902045600..2046319-720WP_094068917.1tol-pal system protein YbgF-
AT395_RS094952046354..2046854-501WP_042115270.1OmpA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1973710..204383870128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6546.79 Da        Isoelectric Point: 11.0075

>T58811 WP_048629124.1 NZ_CP013481:c2043095-2042916 [Pandoraea apista]
MNSSKIIRMLEDDGWKLARITGSHHHFKHPTKPLLVTVPHPKKDLPVGTVKSILKAAGL

Download         Length: 180 bp

>T58811 NZ_CP013481:c2043095-2042916 [Pandoraea apista]
ATGAATTCATCGAAAATCATCCGGATGCTCGAAGATGATGGTTGGAAGTTAGCGCGAATCACTGGCAGCCACCACCACTT
TAAACACCCAACGAAGCCGCTACTTGTGACGGTGCCTCACCCGAAGAAGGATCTGCCAGTTGGGACTGTTAAAAGCATCC
TGAAAGCCGCCGGCCTGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14923.74 Da        Isoelectric Point: 4.5412

>AT58811 WP_048629123.1 NZ_CP013481:c2042841-2042437 [Pandoraea apista]
MEFPIAIHKDDGSVYGVTVPDVPGCFSWGETIDDAIRNAKEAIKGHIETSLEYSEDVTFSCSDIEDLAKREEFAGAVWAL
ADVDVTKLDSKPERINVSFPRFVLHKIDAYVEKRHETRSGFLARVALEALAHEA

Download         Length: 405 bp

>AT58811 NZ_CP013481:c2042841-2042437 [Pandoraea apista]
ATGGAATTTCCCATCGCAATTCATAAGGATGATGGGAGTGTCTATGGAGTGACAGTGCCGGATGTTCCGGGCTGCTTCTC
CTGGGGCGAAACCATCGACGACGCCATCAGGAATGCAAAGGAAGCAATCAAAGGCCATATCGAAACGTCGCTTGAGTATT
CGGAAGATGTGACGTTTTCCTGCTCAGACATCGAGGATTTGGCTAAGCGTGAGGAATTTGCTGGCGCCGTTTGGGCTTTA
GCAGATGTCGATGTAACAAAGCTTGATAGCAAACCGGAGCGCATCAACGTTAGCTTCCCGCGCTTCGTCCTTCACAAGAT
CGATGCTTACGTTGAAAAACGCCATGAGACCCGTAGCGGCTTTCTCGCTCGCGTCGCTTTGGAGGCGCTTGCCCATGAAG
CTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5E5PAN6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5P9T0

References