Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 6021593..6022158 Replicon chromosome
Accession NZ_CP013480
Organism Pandoraea norimbergensis strain DSM 11628

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U2XHN2
Locus tag AT302_RS26445 Protein ID WP_058376537.1
Coordinates 6021787..6022158 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0U2NJE2
Locus tag AT302_RS26440 Protein ID WP_058379966.1
Coordinates 6021593..6021790 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT302_RS26415 6017423..6017857 + 435 WP_058376533.1 flagellar export chaperone FliS -
AT302_RS26420 6017850..6018188 + 339 WP_058376534.1 flagellar protein FliT -
AT302_RS26425 6018259..6019665 + 1407 WP_058376535.1 flagellar hook-length control protein FliK -
AT302_RS26430 6019662..6020030 + 369 WP_084656485.1 EscU/YscU/HrcU family type III secretion system export apparatus switch protein -
AT302_RS26435 6020289..6021488 + 1200 WP_058376536.1 ATP-binding protein -
AT302_RS26440 6021593..6021790 + 198 WP_058379966.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AT302_RS26445 6021787..6022158 + 372 WP_058376537.1 type II toxin-antitoxin system VapC family toxin Toxin
AT302_RS26450 6022334..6022669 - 336 WP_058376538.1 flagellar hook-basal body complex protein FliE -
AT302_RS26455 6022997..6024694 + 1698 WP_058376539.1 flagellar M-ring protein FliF -
AT302_RS26460 6024681..6025679 + 999 WP_084656486.1 flagellar motor switch protein FliG -
AT302_RS26465 6025699..6026358 + 660 WP_058376540.1 flagellar assembly protein FliH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13212.38 Da        Isoelectric Point: 6.8787

>T58810 WP_058376537.1 NZ_CP013480:6021787-6022158 [Pandoraea norimbergensis]
MILVDTSIWIDHLRAGDATLVALLESGRVLAHPYVIGELALGSLKNRSAVIPTLNYLPKATVATDSEVLRFIDEQPLFGL
GIGYVDAHLLAATRLTPGTALWTRDKRLAAIAESLSLAAKLSH

Download         Length: 372 bp

>T58810 NZ_CP013480:6021787-6022158 [Pandoraea norimbergensis]
ATGATCTTAGTCGACACTTCGATATGGATTGATCACTTGCGCGCAGGCGACGCGACGCTGGTCGCCTTACTTGAGTCCGG
CCGGGTACTGGCTCACCCCTATGTGATCGGAGAATTGGCGCTTGGTAGTCTCAAGAACCGATCGGCGGTGATTCCGACCT
TGAATTACCTGCCTAAGGCGACTGTCGCAACCGACAGCGAGGTGCTGCGATTCATCGACGAGCAACCGCTGTTCGGCTTA
GGAATCGGCTACGTCGACGCTCATCTGCTCGCGGCAACTCGCCTCACGCCAGGGACCGCGCTTTGGACACGCGACAAGCG
CCTCGCTGCGATAGCGGAAAGTCTTTCATTGGCGGCGAAACTGTCGCACTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7180.17 Da        Isoelectric Point: 5.0959

>AT58810 WP_058379966.1 NZ_CP013480:6021593-6021790 [Pandoraea norimbergensis]
MRTTLALDDDLVATAQAFTGLQEKSALVREALKALIERESARRLARLGGTEAEIEDIVRRRSEPA

Download         Length: 198 bp

>AT58810 NZ_CP013480:6021593-6021790 [Pandoraea norimbergensis]
ATGCGGACCACGCTCGCCCTTGATGACGACCTTGTTGCAACGGCGCAGGCCTTCACTGGCTTGCAGGAAAAGTCGGCACT
TGTCCGGGAGGCCCTTAAGGCCTTGATCGAGCGTGAGAGCGCTCGTCGCTTGGCTCGCTTGGGTGGCACCGAAGCCGAAA
TTGAGGACATTGTGCGCCGCCGGTCGGAGCCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U2XHN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U2NJE2

References