Detailed information of TA system TA058809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 5957529..5958048
• Replicon: chromosome
• Accession: NZ_CP013480
• Organism: Pandoraea norimbergensis strain DSM 11628

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AT302_RS27445
• Protein ID: WP_084656480.1
• Coordinates: 5957758..5958048 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0U2W714
• Locus tag: AT302_RS26170
• Protein ID: WP_058376491.1
• Coordinates: 5957529..5957771 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT302_RS27780	5953637..5954164	-	528	WP_058376486.1	hypothetical protein	-
AT302_RS26150	5954278..5955051	-	774	WP_058376487.1	BON domain-containing protein	-
AT302_RS26155	5955171..5955758	-	588	WP_058376488.1	phosphoheptose isomerase	-
AT302_RS26160	5955934..5956287	-	354	WP_058376489.1	YraN family protein	-
AT302_RS26165	5956455..5957339	+	885	WP_058376490.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
AT302_RS26170	5957529..5957771	+	243	WP_058376491.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AT302_RS27445	5957758..5958048	+	291	WP_084656480.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AT302_RS26180	5958124..5958918	-	795	WP_058376493.1	ABC transporter ATP-binding protein	-
AT302_RS26185	5958921..5959829	-	909	WP_058376494.1	ABC transporter permease	-
AT302_RS26190	5959998..5960984	-	987	WP_058376495.1	ABC transporter substrate-binding protein	-
AT302_RS26195	5961481..5962083	-	603	WP_058376496.1	septal ring lytic transglycosylase RlpA family protein	-
AT302_RS26200	5962330..5962986	+	657	WP_058376497.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-64)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11075.02 Da
• Isoelectric Point: 11.4465

>T58809 WP_084656480.1 NZ_CP013480:5957758-5958048 [Pandoraea norimbergensis]
MTTYDLQFLPSALKEWRALDPTIAQQFKARLRDRLRHPRVAASQLRAMPGCYKIKLASVGYRLVYRVEDATVTVLVLAVG
KRENLAAYRTGRRRIQ

Nucleotide

• Length: 291 bp

>T58809 NZ_CP013480:5957758-5958048 [Pandoraea norimbergensis]
TTGACGACCTATGACCTGCAATTCTTACCTTCTGCCCTCAAAGAATGGCGGGCGCTTGACCCCACCATTGCGCAGCAATT
CAAAGCACGCTTACGAGATCGCCTGCGACATCCTCGCGTAGCCGCCAGCCAACTGCGTGCGATGCCGGGTTGCTACAAGA
TAAAACTCGCGTCGGTCGGTTATCGACTCGTGTACCGCGTTGAAGACGCGACTGTCACCGTTCTCGTGCTGGCCGTCGGA
AAGCGCGAAAATCTTGCGGCTTATCGCACCGGGCGCCGACGGATTCAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8626.89 Da
• Isoelectric Point: 4.5257

>AT58809 WP_058376491.1 NZ_CP013480:5957529-5957771 [Pandoraea norimbergensis]
MKNILARASIGISELKLNPSAAIERADGPVAILNRNKPVAYLIPAADWEAICDRLDDAELADIIRSRAGETPVSTKLDDL

Nucleotide

• Length: 243 bp

>AT58809 NZ_CP013480:5957529-5957771 [Pandoraea norimbergensis]
ATGAAAAACATCCTAGCCCGCGCATCGATCGGAATCAGCGAATTGAAACTGAACCCCAGCGCCGCCATTGAGCGCGCCGA
CGGCCCCGTCGCCATCCTGAATCGCAATAAACCCGTGGCCTACCTGATCCCTGCCGCCGATTGGGAAGCCATTTGCGACC
GCCTTGACGACGCCGAACTCGCCGACATCATCCGCTCGCGTGCCGGCGAAACGCCGGTGAGTACGAAGCTTGACGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0U2W714