Detailed information of TA system TA058808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 5602500..5603086
• Replicon: chromosome
• Accession: NZ_CP013480
• Organism: Pandoraea norimbergensis strain DSM 11628

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AT302_RS27410
• Protein ID: WP_084656445.1
• Coordinates: 5602500..5602754 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0U2WEW0
• Locus tag: AT302_RS24520
• Protein ID: WP_058376236.1
• Coordinates: 5602751..5603086 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT302_RS24500	5597702..5598454	-	753	WP_058376232.1	DsbC family protein	-
AT302_RS24505	5598579..5599766	-	1188	WP_058376233.1	UbiH/UbiF family hydroxylase	-
AT302_RS24510	5599961..5600839	+	879	WP_058376234.1	neutral zinc metallopeptidase	-
AT302_RS24515	5600949..5602043	+	1095	WP_058376235.1	redox-regulated ATPase YchF	-
AT302_RS27410	5602500..5602754	+	255	WP_084656445.1	type II toxin-antitoxin system HicA family toxin	Toxin
AT302_RS24520	5602751..5603086	+	336	WP_058376236.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AT302_RS24525	5603567..5603935	-	369	WP_084656653.1	GNAT family N-acetyltransferase	-
AT302_RS24530	5604037..5604717	-	681	WP_058376237.1	GntR family transcriptional regulator	-
AT302_RS24535	5604779..5606224	+	1446	WP_058376238.1	anion permease	-
AT302_RS24540	5606592..5607893	+	1302	WP_058376239.1	DUF2029 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9565.12 Da
• Isoelectric Point: 10.7978

>T58808 WP_084656445.1 NZ_CP013480:5602500-5602754 [Pandoraea norimbergensis]
MKTKSRKTLELIFSRPTPAGARWRDVASLFLDLGAELIEREGSRVAVYLFGHIRIFHRPHPSPDLDKGAIATIRKWLEEN
GVKP

Nucleotide

• Length: 255 bp

>T58808 NZ_CP013480:5602500-5602754 [Pandoraea norimbergensis]
ATGAAAACAAAATCGAGAAAGACGCTTGAATTGATTTTTTCTCGCCCCACCCCAGCGGGAGCGCGTTGGCGCGACGTGGC
ATCGCTGTTTCTTGATCTTGGTGCAGAGTTGATTGAACGCGAGGGGTCCCGAGTCGCGGTCTATTTGTTTGGCCACATCA
GAATATTTCATCGCCCCCACCCTTCGCCGGACCTCGACAAGGGGGCTATTGCAACGATTCGGAAGTGGCTCGAAGAGAAC
GGAGTGAAACCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12002.67 Da
• Isoelectric Point: 5.1372

>AT58808 WP_058376236.1 NZ_CP013480:5602751-5603086 [Pandoraea norimbergensis]
MNNVMIINGHKAVICYDPEIEMFRGEFVGLNGGADFYAGDVGGLHREGELSLKVFLEECARRGLEPQKQFSGKFVIRLDP
KAHEAAAIAAAAHGQSLNQWAAETLELAACA

Nucleotide

• Length: 336 bp

>AT58808 NZ_CP013480:5602751-5603086 [Pandoraea norimbergensis]
ATGAATAACGTCATGATCATCAATGGGCACAAGGCCGTCATCTGCTATGACCCCGAGATTGAAATGTTCAGAGGCGAGTT
TGTCGGCTTGAACGGGGGTGCAGATTTTTATGCCGGTGATGTCGGCGGACTGCATCGCGAAGGCGAACTGTCTTTGAAGG
TCTTTCTCGAAGAATGCGCGCGCCGTGGTTTGGAACCCCAAAAGCAGTTTTCGGGGAAGTTTGTGATTCGCCTGGATCCC
AAAGCCCATGAAGCTGCCGCTATTGCCGCCGCAGCGCACGGACAAAGTCTGAACCAGTGGGCAGCCGAGACACTTGAGCT
CGCGGCGTGCGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0U2WEW0