Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4615020..4616895 Replicon chromosome
Accession NZ_CP013480
Organism Pandoraea norimbergensis strain DSM 11628

Toxin (Protein)


Gene name doc Uniprot ID A0A0U2MII0
Locus tag AT302_RS20090 Protein ID WP_058379808.1
Coordinates 4615972..4616895 (-) Length 308 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0U2WSC8
Locus tag AT302_RS20085 Protein ID WP_058379807.1
Coordinates 4615020..4615889 (-) Length 290 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT302_RS20065 4610245..4611741 - 1497 WP_058375527.1 aldehyde dehydrogenase -
AT302_RS20070 4611761..4612579 - 819 WP_058375528.1 aspartate dehydrogenase -
AT302_RS20075 4612572..4614224 - 1653 WP_058375529.1 thiamine pyrophosphate-binding protein -
AT302_RS20080 4614217..4615023 - 807 WP_058375530.1 SDR family oxidoreductase -
AT302_RS20085 4615020..4615889 - 870 WP_058379807.1 IclR family transcriptional regulator Antitoxin
AT302_RS20090 4615972..4616895 - 924 WP_058379808.1 alpha/beta hydrolase Toxin
AT302_RS20095 4617004..4617561 - 558 WP_058375531.1 cupin domain-containing protein -
AT302_RS20100 4617616..4618407 - 792 WP_084656354.1 SDR family oxidoreductase -
AT302_RS20105 4618450..4619232 - 783 WP_058375532.1 ABC transporter permease -
AT302_RS20110 4619276..4620142 - 867 WP_157125841.1 ABC transporter ATP-binding protein -
AT302_RS20115 4620481..4621557 - 1077 WP_058379811.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(58-293)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 31653.77 Da        Isoelectric Point: 5.3192

>T58807 WP_058379808.1 NZ_CP013480:c4616895-4615972 [Pandoraea norimbergensis]
MSAEALKSELPDANDANDGIVAPLCARLNAFAYRTIVTRAGTVGYRSTATADDGRIAVVMLHGIGSGAASWLAQFEAAGL
DVALYAWDAPGYGQTSNVSDAEPHADAYADALEAWLDALGLDRVALVGHSLGAIMATKFASRAPQRVRGLFLCSPAGGYG
KADPAVRVSKRDSRLAMLDKLGPAGIARERSDNLVAPNAADLPRAWVKWNMSRVLPAGYRQATHLLSNGDVAGELAQYVA
ANAGPVAVAVGAQDGITTPAACQVIADVAGVPLQIIDGAGHASYIETPDVLNAALAAWLDRVAAGGR

Download         Length: 924 bp

>T58807 NZ_CP013480:c4616895-4615972 [Pandoraea norimbergensis]
ATGTCAGCCGAAGCTCTCAAGTCCGAACTGCCCGACGCCAACGACGCCAACGACGGCATCGTCGCCCCGCTTTGCGCGCG
ACTGAATGCGTTTGCGTATCGCACCATCGTCACGCGTGCAGGGACGGTCGGCTATCGCAGCACCGCCACGGCTGACGACG
GGCGCATTGCGGTCGTGATGCTGCACGGCATCGGCTCGGGCGCCGCGTCGTGGCTTGCCCAGTTCGAAGCGGCCGGTCTG
GATGTCGCGTTGTATGCGTGGGATGCACCGGGCTACGGCCAGACGTCGAATGTGAGCGATGCCGAACCGCACGCCGACGC
CTACGCCGATGCGCTCGAAGCATGGCTCGACGCGCTGGGTCTGGATCGCGTCGCGCTGGTTGGACACTCGCTCGGCGCGA
TCATGGCGACGAAGTTCGCCAGCCGTGCGCCGCAGCGCGTGCGCGGCCTCTTTCTCTGCTCGCCGGCGGGCGGCTACGGC
AAGGCCGATCCGGCAGTCCGAGTGTCGAAGCGCGACAGCCGTCTGGCGATGCTCGACAAACTCGGGCCGGCCGGCATTGC
GCGCGAGCGCAGCGACAACTTGGTCGCGCCGAATGCTGCGGACCTGCCGCGCGCTTGGGTGAAATGGAATATGAGCCGTG
TGCTGCCCGCGGGTTATCGGCAGGCAACGCATCTGCTGTCGAACGGCGATGTCGCAGGCGAGTTGGCGCAGTACGTGGCC
GCCAACGCTGGGCCGGTGGCCGTGGCCGTCGGCGCGCAGGACGGCATTACGACGCCCGCCGCCTGTCAGGTCATTGCCGA
CGTGGCCGGTGTGCCGTTGCAAATCATCGACGGCGCAGGCCATGCGTCGTATATCGAAACCCCCGACGTCCTGAATGCTG
CGCTCGCGGCATGGCTGGACCGGGTGGCGGCGGGAGGGCGTTGA

Antitoxin


Download         Length: 290 a.a.        Molecular weight: 31493.94 Da        Isoelectric Point: 6.6557

>AT58807 WP_058379807.1 NZ_CP013480:c4615889-4615020 [Pandoraea norimbergensis]
MSDQDAEGDAADAGPSESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTTVFRLLQTLEAMGFLERAGSEKNF
RLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSVAGVFNSIKVNVGTRLPAHATVHG
HVLMGDLTLTELKALYPEKTLEKFTPQTPETLAELFERVREDAERGYAVSASSFERGISVVSAPVRSDTGRICAAITVTI
PRANIDASMLDAGLIGQVREAADALSHRLNYRPGSDGRTTPYMKSLGLK

Download         Length: 870 bp

>AT58807 NZ_CP013480:c4615889-4615020 [Pandoraea norimbergensis]
ATGAGCGACCAAGACGCCGAAGGCGATGCCGCTGACGCCGGACCGTCCGAGTCACGCTATCTCGTGCCGGGGCTGGAGCG
CGGTTTGCGCATCCTCACGCAGTTCTCGCCGCGCGAATCCGTGTTCAGCGCGCCGGAATTGTCGCAGCGTCTCGGCATTC
CGCGCACCACTGTATTCCGTCTGTTGCAGACGCTCGAAGCCATGGGGTTTCTGGAGCGCGCAGGCAGTGAAAAGAACTTC
CGTCTAGGCGTTGCCGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTGGGCATTCCGATCAT
CGAGCGCTTGCGCGACGCGACCCAACTCACTTCGCACATCGTGATTCGCGATGGCCGCGACATCGTCTTCGTGGCGAAGG
CGCAGAGCGTGGCGGGCGTGTTCAATTCGATCAAGGTGAACGTCGGCACGCGCTTGCCCGCCCATGCGACGGTCCATGGC
CACGTGCTCATGGGCGATCTGACGCTGACCGAACTCAAGGCGCTTTACCCAGAAAAAACGCTGGAGAAATTCACGCCGCA
AACGCCTGAGACGCTCGCCGAGCTTTTCGAGCGCGTGCGCGAAGACGCCGAGCGTGGCTATGCCGTGTCGGCCTCGTCGT
TCGAGCGCGGCATCAGCGTGGTGAGCGCACCGGTGCGCAGCGACACGGGCCGCATTTGCGCGGCTATTACGGTCACGATT
CCGCGCGCCAACATCGATGCGTCGATGCTCGATGCGGGCCTGATTGGCCAAGTGCGTGAAGCCGCCGATGCGCTGTCGCA
CCGTCTGAATTACCGGCCGGGCAGTGACGGCCGGACCACCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U2MII0

Antitoxin

Source ID Structure
AlphaFold DB A0A0U2WSC8

References