58766

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2241848..2242474 Replicon chromosome
Accession NZ_CP013475
Organism Mycobacterium tuberculosis strain 1458

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag BTB1458_RS10520 Protein ID WP_003410075.1
Coordinates 2242076..2242474 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag BTB1458_RS10515 Protein ID WP_003911750.1
Coordinates 2241848..2242075 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTB1458_RS10505 2239887..2240231 - 345 WP_003410065.1 ferredoxin family protein -
BTB1458_RS10510 2240420..2241589 - 1170 WP_003899126.1 ATP-binding protein -
BTB1458_RS10515 2241848..2242075 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BTB1458_RS10520 2242076..2242474 + 399 WP_003410075.1 PIN domain nuclease Toxin
BTB1458_RS10525 2242657..2243088 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
BTB1458_RS10530 2243189..2243623 + 435 WP_003914358.1 DUF1398 domain-containing protein -
BTB1458_RS21280 2244060..2244239 - 180 Protein_2064 hypothetical protein -
BTB1458_RS10535 2244300..2244947 + 648 WP_071854215.1 transposase -
BTB1458_RS10540 2244901..2245491 + 591 WP_003899131.1 IS110 family transposase -
BTB1458_RS10545 2245619..2246875 - 1257 WP_003902247.1 HNH endonuclease -
BTB1458_RS10550 2247229..2247429 + 201 Protein_2068 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T58766 WP_003410075.1 NZ_CP013475:2242076-2242474 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T58766 NZ_CP013475:2242076-2242474 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT58766 WP_003911750.1 NZ_CP013475:2241848-2242075 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT58766 NZ_CP013475:2241848-2242075 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References