Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2184907..2185451 Replicon chromosome
Accession NZ_CP013475
Organism Mycobacterium tuberculosis strain 1458

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag BTB1458_RS10210 Protein ID WP_003409896.1
Coordinates 2184907..2185203 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag BTB1458_RS10215 Protein ID WP_003409899.1
Coordinates 2185200..2185451 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTB1458_RS10155 2179940..2180290 - 351 WP_003409871.1 hypothetical protein -
BTB1458_RS10160 2180301..2181203 - 903 WP_003899097.1 hypothetical protein -
BTB1458_RS10165 2181224..2181415 - 192 WP_003409876.1 hypothetical protein -
BTB1458_RS10170 2181416..2181712 - 297 WP_003409877.1 hypothetical protein -
BTB1458_RS10175 2181952..2182167 + 216 WP_003409878.1 antitoxin -
BTB1458_RS10180 2182164..2182475 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
BTB1458_RS22380 2182449..2182970 - 522 WP_003904745.1 hypothetical protein -
BTB1458_RS10190 2182945..2183322 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
BTB1458_RS10195 2183364..2183813 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
BTB1458_RS10200 2183810..2184355 + 546 WP_003409891.1 SecB-like chaperone -
BTB1458_RS10205 2184244..2184858 - 615 WP_003901296.1 hypothetical protein -
BTB1458_RS10210 2184907..2185203 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTB1458_RS10215 2185200..2185451 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BTB1458_RS10220 2185438..2185932 + 495 WP_003899099.1 hypothetical protein -
BTB1458_RS10225 2186092..2186499 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
BTB1458_RS10230 2186503..2186775 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BTB1458_RS10235 2186808..2188028 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
BTB1458_RS10245 2188927..2189724 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T58762 WP_003409896.1 NZ_CP013475:c2185203-2184907 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T58762 NZ_CP013475:c2185203-2184907 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT58762 WP_003409899.1 NZ_CP013475:c2185451-2185200 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT58762 NZ_CP013475:c2185451-2185200 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References