Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 710665..711314 Replicon chromosome
Accession NZ_CP013475
Organism Mycobacterium tuberculosis strain 1458

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag BTB1458_RS03225 Protein ID WP_003403236.1
Coordinates 710919..711314 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag BTB1458_RS03220 Protein ID WP_003403235.1
Coordinates 710665..710919 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTB1458_RS20790 705791..706486 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
BTB1458_RS20795 706483..706974 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
BTB1458_RS03200 706971..708062 + 1092 WP_003900977.1 galactokinase -
BTB1458_RS03210 708457..709521 + 1065 WP_003898532.1 hypothetical protein -
BTB1458_RS03215 709625..710572 + 948 WP_003403232.1 DUF732 domain-containing protein -
BTB1458_RS03220 710665..710919 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
BTB1458_RS03225 710919..711314 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
BTB1458_RS03230 711408..712148 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
BTB1458_RS03235 712280..712540 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BTB1458_RS03240 712537..712944 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
BTB1458_RS03245 713016..714167 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
BTB1458_RS03250 714260..715987 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T58741 WP_003403236.1 NZ_CP013475:710919-711314 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T58741 NZ_CP013475:710919-711314 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT58741 WP_003403235.1 NZ_CP013475:710665-710919 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT58741 NZ_CP013475:710665-710919 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References