Detailed information of TA system TA058727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 146226..146863
• Replicon: chromosome
• Accession: NZ_CP013467
• Organism: Burkholderia multivorans strain MSMB1640WGS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WM33_RS11280
• Protein ID: WP_048805442.1
• Coordinates: 146462..146863 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: WM33_RS11275
• Protein ID: WP_048805443.1
• Coordinates: 146226..146462 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM33_RS11250	141376..141918	+	543	WP_048805448.1	hypothetical protein	-
WM33_RS11255	142082..143113	+	1032	WP_048805447.1	helix-turn-helix domain-containing protein	-
WM33_RS11265	143241..144338	-	1098	WP_048805445.1	ADP-heptose--LPS heptosyltransferase	-
WM33_RS11270	144335..146038	-	1704	WP_048805444.1	thiamine pyrophosphate-binding protein	-
WM33_RS11275	146226..146462	+	237	WP_048805443.1	AbrB family transcriptional regulator	Antitoxin
WM33_RS11280	146462..146863	+	402	WP_048805442.1	type II toxin-antitoxin system VapC family toxin	Toxin
WM33_RS11285	146975..148363	-	1389	WP_006401425.1	L-serine ammonia-lyase	-
WM33_RS11290	148390..149532	-	1143	WP_006401424.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14965.10 Da
• Isoelectric Point: 5.2054

>T58727 WP_048805442.1 NZ_CP013467:146462-146863 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFAGYPGLRLENWLTD

Nucleotide

• Length: 402 bp

>T58727 NZ_CP013467:146462-146863 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGGTATGTGCCAATC
CGGCGCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGCGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCGGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGGGTTATCCGGGCTTGAGGCTCGAGAACTGGCTGACCGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8985.09 Da
• Isoelectric Point: 5.1651

>AT58727 WP_048805443.1 NZ_CP013467:146226-146462 [Burkholderia multivorans]
MHITRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREDW

Nucleotide

• Length: 237 bp

>AT58727 NZ_CP013467:146226-146462 [Burkholderia multivorans]
ATGCATATCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTGGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGATGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGATTGGTGA