Detailed information of TA system TA058726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1897053..1898323
• Replicon: chromosome
• Accession: NZ_CP013466
• Organism: Burkholderia multivorans strain MSMB1640WGS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WM33_RS08115
• Protein ID: WP_060139943.1
• Coordinates: 1897745..1898323 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: WM33_RS08110
• Protein ID: WP_048804461.1
• Coordinates: 1897053..1897610 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM33_RS08090	1892133..1893149	+	1017	WP_006412465.1	AraC family transcriptional regulator	-
WM33_RS08095	1893255..1893893	+	639	WP_048804463.1	cysteine hydrolase	-
WM33_RS08100	1894066..1894797	-	732	WP_035955446.1	ribonuclease T2	-
WM33_RS08105	1895139..1896542	-	1404	WP_048804462.1	membrane protein	-
WM33_RS08110	1897053..1897610	+	558	WP_048804461.1	helix-turn-helix domain-containing protein	Antitoxin
WM33_RS08115	1897745..1898323	+	579	WP_060139943.1	HD domain-containing protein	Toxin
WM33_RS08120	1898418..1899956	-	1539	WP_048804459.1	MFS transporter	-
WM33_RS08125	1900135..1901055	+	921	WP_035955455.1	LysR family transcriptional regulator	-
WM33_RS08130	1901108..1902247	-	1140	WP_048804458.1	enoyl-CoA hydratase/isomerase family protein	-
WM33_RS08135	1902244..1903035	-	792	WP_048804457.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-172)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21340.08 Da
• Isoelectric Point: 5.3191

>T58726 WP_060139943.1 NZ_CP013466:1897745-1898323 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNLHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQART

Nucleotide

• Length: 579 bp

>T58726 NZ_CP013466:1897745-1898323 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGACAAGAACCTGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTGCGTAACGAACTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGATGCGGCACCGCTATTCAGCGCGATCCGGGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACGAACGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20349.35 Da
• Isoelectric Point: 8.5490

>AT58726 WP_048804461.1 NZ_CP013466:1897053-1897610 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT58726 NZ_CP013466:1897053-1897610 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCATACGCCGCCGCTCGGCCCGCAGCTGAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGCGCTATTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCGGAACGTCTGCTCGCCGCGCGCCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGACTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGCACGAACGCATCGCGCGTCGTGCCG
ATCCACCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGGTCGGCGGCACGGCTCGTCGAAACGCTGTAG