Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1232576..1233110 Replicon chromosome
Accession NZ_CP013466
Organism Burkholderia multivorans strain MSMB1640WGS

Toxin (Protein)


Gene name parE Uniprot ID J4RBB5
Locus tag WM33_RS05465 Protein ID WP_006413674.1
Coordinates 1232811..1233110 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J4RB90
Locus tag WM33_RS05460 Protein ID WP_006413656.1
Coordinates 1232576..1232821 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM33_RS05445 1227622..1229325 + 1704 WP_048803633.1 VRR-NUC domain-containing protein -
WM33_RS05450 1229322..1231622 + 2301 WP_048804736.1 ATP-dependent DNA helicase -
WM33_RS05455 1231667..1232437 - 771 WP_006403543.1 helix-turn-helix domain-containing protein -
WM33_RS05460 1232576..1232821 + 246 WP_006413656.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
WM33_RS05465 1232811..1233110 + 300 WP_006413674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM33_RS05470 1233219..1234520 - 1302 WP_006413706.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
WM33_RS05475 1234691..1235419 + 729 WP_048803632.1 HNH endonuclease -
WM33_RS05480 1235453..1236760 - 1308 WP_012216990.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11542.08 Da        Isoelectric Point: 8.4461

>T58722 WP_006413674.1 NZ_CP013466:1232811-1233110 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLGQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T58722 NZ_CP013466:1232811-1233110 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCACTGGCGGAGGCCGATCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCACTCGGCCAGGCTGAGCGCTATATCGGCGAGCTGAGCACGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGTCGCGCGGGCGGCAACTATTCGCGCTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.71 Da        Isoelectric Point: 6.4604

>AT58722 WP_006413656.1 NZ_CP013466:1232576-1232821 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT58722 NZ_CP013466:1232576-1232821 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCCCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KLL7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KUX0

References