Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 441482..442102 Replicon chromosome
Accession NZ_CP013466
Organism Burkholderia multivorans strain MSMB1640WGS

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag WM33_RS02045 Protein ID WP_012217495.1
Coordinates 441785..442102 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag WM33_RS02040 Protein ID WP_006398012.1
Coordinates 441482..441781 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM33_RS02015 436724..437992 + 1269 WP_048803965.1 Rieske 2Fe-2S domain-containing protein -
WM33_RS02020 438007..438495 + 489 WP_006398008.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WM33_RS02025 438513..438839 + 327 WP_048803964.1 non-heme iron oxygenase ferredoxin subunit -
WM33_RS02030 438829..440049 + 1221 WP_048803963.1 FAD-dependent oxidoreductase -
WM33_RS02035 440166..441452 + 1287 WP_048803962.1 DUF445 domain-containing protein -
WM33_RS02040 441482..441781 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
WM33_RS02045 441785..442102 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM33_RS02050 442465..444105 + 1641 WP_006398015.1 acetolactate synthase large subunit -
WM33_RS02055 444134..445567 + 1434 WP_048803961.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T58720 WP_012217495.1 NZ_CP013466:c442102-441785 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T58720 NZ_CP013466:c442102-441785 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT58720 WP_006398012.1 NZ_CP013466:c441781-441482 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT58720 NZ_CP013466:c441781-441482 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
CTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCACTCGGCCTGCAACTGCACGGCGCGAAAGCACACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References