Detailed information of TA system TA058719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2380094..2381312
• Replicon: chromosome
• Accession: NZ_CP013464
• Organism: Burkholderia ubonensis strain MSMB1471WGS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WM29_RS26515
• Protein ID: WP_060307132.1
• Coordinates: 2380731..2381312 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A124ZE89
• Locus tag: WM29_RS26510
• Protein ID: WP_059588899.1
• Coordinates: 2380094..2380651 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM29_RS26490	2375603..2376541	-	939	WP_069238030.1	S1C family serine protease	-
WM29_RS26495	2376970..2377386	-	417	WP_045563786.1	hypothetical protein	-
WM29_RS26500	2377720..2378451	-	732	WP_029226220.1	ribonuclease T2	-
WM29_RS26505	2378586..2379962	-	1377	WP_069238031.1	hypothetical protein	-
WM29_RS26510	2380094..2380651	+	558	WP_059588899.1	helix-turn-helix domain-containing protein	Antitoxin
WM29_RS26515	2380731..2381312	+	582	WP_060307132.1	HD domain-containing protein	Toxin
WM29_RS26520	2381467..2382657	+	1191	WP_069238032.1	macrolide transporter subunit MacA	-
WM29_RS26525	2382660..2384708	+	2049	WP_069238033.1	MacB family efflux pump subunit	-
WM29_RS26530	2384714..2386090	+	1377	WP_069238034.1	efflux transporter outer membrane subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-186)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-61)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21215.90 Da
• Isoelectric Point: 5.7922

>T58719 WP_060307132.1 NZ_CP013464:2380731-2381312 [Burkholderia ubonensis]
MTPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALDGVDPLKLLKLCVVHDLGEALHGDIP
AVEQAAHPDKSAHERRDLLALTAGLDAAPRDEIVALWDEYERAASPEAKAVKALDKLETILQHNQGDNPPDFDYAFNLGY
GRRHTDASPLFRAIRAIIDADTQSRIDAGARRA

Nucleotide

• Length: 582 bp

>T58719 NZ_CP013464:2380731-2381312 [Burkholderia ubonensis]
ATGACTCCCGACACGATCCACGCACGGCTCGCGTTCCTGCGCGAAGCGGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTGGTGTTCGCCGACGCGC
TCGACGGCGTCGACCCGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTGGGCGAGGCGCTGCACGGCGACATCCCG
GCGGTCGAGCAGGCCGCGCATCCGGACAAGAGCGCGCACGAGCGGCGCGACCTGCTCGCGCTGACCGCCGGCCTCGACGC
CGCGCCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGCGGGCCGCGTCGCCGGAAGCGAAGGCCGTCAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCGACAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCCATACGGACGCAAGCCCGCTGTTCCGCGCGATCCGGGCGATCATCGACGCCGACACGCAAAGCCGGATCGA
CGCCGGCGCACGGCGCGCGTGA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20243.30 Da
• Isoelectric Point: 10.0972

>AT58719 WP_059588899.1 NZ_CP013464:2380094-2380651 [Burkholderia ubonensis]
MTDSPLQTPPLGPLLKRWRLLRRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERAIAERLLAARLDSAGDRALARLVGD
HPGRVHLVCDLTHRLLACSSLRAAEFAKPLPTMLGASLWRYATPEIAALEASLDTLGWRDSAGPPSVEFDSGANASRIVP
IRRSTCRWTRMILSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT58719 NZ_CP013464:2380094-2380651 [Burkholderia ubonensis]
ATGACCGACTCGCCGCTTCAAACGCCGCCGCTCGGCCCGCTGCTGAAGCGCTGGCGGCTCCTGCGCCGCGTAAAGCAAAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAGTCGACGATTTCCCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGATCGCCGAGCGCCTGCTCGCGGCGCGGCTCGATTCCGCCGGCGACCGCGCGCTCGCGCGGCTCGTCGGCGAC
CATCCCGGCCGCGTGCACCTCGTGTGCGACCTCACGCATCGGCTGCTGGCGTGCTCGTCGCTGCGCGCCGCCGAGTTCGC
GAAACCGCTGCCGACGATGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCGCGCTGGAAGCGTCGCTCG
ATACGCTCGGCTGGCGCGACAGCGCCGGGCCGCCGAGCGTCGAGTTCGACAGCGGCGCGAATGCGTCGCGCATCGTGCCG
ATCCGTCGCAGCACCTGCCGCTGGACGCGGATGATCCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A124ZE89