58717

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2005999..2007746 Replicon chromosome
Accession NZ_CP013464
Organism Burkholderia ubonensis strain MSMB1471WGS

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WM29_RS24875 Protein ID WP_059963661.1
Coordinates 2006847..2007746 (-) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A105IWC1
Locus tag WM29_RS24870 Protein ID WP_059963658.1
Coordinates 2005999..2006850 (-) Length 284 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM29_RS24850 2001203..2002693 - 1491 WP_060323990.1 aldehyde dehydrogenase -
WM29_RS24855 2002716..2003549 - 834 WP_069237936.1 aspartate dehydrogenase -
WM29_RS24860 2003542..2005209 - 1668 WP_069237937.1 thiamine pyrophosphate-binding protein -
WM29_RS24865 2005202..2005999 - 798 WP_059963656.1 SDR family oxidoreductase -
WM29_RS24870 2005999..2006850 - 852 WP_059963658.1 IclR family transcriptional regulator Antitoxin
WM29_RS24875 2006847..2007746 - 900 WP_059963661.1 alpha/beta fold hydrolase Toxin
WM29_RS24880 2007765..2008292 - 528 WP_010089663.1 cupin domain-containing protein -
WM29_RS24885 2008319..2009089 - 771 WP_059963664.1 SDR family oxidoreductase -
WM29_RS24890 2009082..2010152 - 1071 WP_059963667.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WM29_RS24895 2010195..2010506 - 312 WP_059963669.1 hypothetical protein -
WM29_RS24900 2010510..2010827 - 318 WP_017329029.1 non-heme iron oxygenase ferredoxin subunit -
WM29_RS24905 2011264..2012343 + 1080 WP_069237938.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(52-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 30717.91 Da        Isoelectric Point: 7.7458

>T58717 WP_059963661.1 NZ_CP013464:c2007746-2006847 [Burkholderia ubonensis]
MSVIDKRERDRERIASFAALLERFPEQRSPAGAAGTIGYRAAGAGEGGALPVVLLHGIGSGAASWVRQFDALGASRRVFA
WDAPGYGASTPVYGASPAASDYAAALGAWLDALGIDRCVLVGHSLGAIIAGGFARVMPERIAGLLLISPAGGYGSAPAET
RASRRDARLAMLDELGPAGLAAQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAAFRGRTAVAV
GANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDLQRGLA

Download         Length: 900 bp

>T58717 NZ_CP013464:c2007746-2006847 [Burkholderia ubonensis]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCGAGCGCATCGCGAGCTTCGCAGCGCTGCTCGAGCGGTTTCCCGAGCA
GCGCTCGCCGGCCGGCGCGGCGGGCACGATCGGCTACCGCGCGGCCGGCGCAGGCGAGGGCGGCGCGCTCCCCGTCGTGC
TGCTGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGTTCGATGCGCTCGGCGCTTCGCGGCGCGTGTTCGCA
TGGGATGCGCCCGGCTACGGCGCGTCGACGCCCGTGTACGGCGCATCGCCGGCCGCATCCGACTACGCGGCGGCGCTCGG
CGCGTGGCTCGATGCGCTCGGCATCGACCGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGCTTCG
CCCGCGTGATGCCGGAGCGCATTGCCGGGCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCGGCCGAGACG
CGCGCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGACGAACTCGGCCCGGCGGGGCTCGCGGCGCAGCGCAGCGGCAA
CATGCTGTCCGGCTTTGCGAGCGAGGACGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACG
CGCAGGCGACGCATCTGCTCGCGAACGCCGATCTCGCGTCGGACCTCGCGGCCTTTCGCGGCCGCACGGCGGTGGCCGTC
GGCGCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGGCGGCCGCGCACGTCGGGCTGCAGGTGATTCC
GCAGGCCGGACATGCGGGCTACGTCGAGGCGCCGGCCGTCTATTCCGCACTGATCGACGCGTTCTGCCGTCAGTGCGACC
TGCAGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 284 a.a.        Molecular weight: 31006.45 Da        Isoelectric Point: 6.3566

>AT58717 WP_059963658.1 NZ_CP013464:c2006850-2005999 [Burkholderia ubonensis]
MSEPLLNENDGAKGDANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLGELRALYPEGTLNRMTNATPDTVDALYDMIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDAALIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGL

Download         Length: 852 bp

>AT58717 NZ_CP013464:c2006850-2005999 [Burkholderia ubonensis]
ATGAGCGAACCGCTGCTGAATGAAAACGACGGCGCGAAGGGCGACGCGAACTACGTGGTGCCGGGCCTCGAACGGGGCTT
GAGGATACTCGCGGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGACGCGACCGGGTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
GCCAGGCGCCGGTGTTCAGCTCGATCCGGGTGAACGTCGGCACGCGGCTGCCCGCGCACGCGACCACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGGGCGAGCTGCGCGCGCTGTATCCGGAGGGCACGCTCAACCGGATGACGAACGCGACGCC
GGACACGGTCGACGCGTTGTACGACATGATCCGCGAGGATGCGTTGCGCGGCTACGGCGTCAGCAACTCGTCGTTCGAGC
GCGGCATCTCGGTCGTCACCGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCGGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAACTATCGCTCGGACGACGAGCATACGTTTCTGAAGGCTTTGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A105IWC1

References