58713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1766650..1767326 Replicon chromosome
Accession NZ_CP013463
Organism Burkholderia ubonensis strain MSMB1471WGS

Toxin (Protein)


Gene name vagD Uniprot ID A0A105INJ6
Locus tag WM29_RS08085 Protein ID WP_059965048.1
Coordinates 1766910..1767326 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A118MA44
Locus tag WM29_RS08080 Protein ID WP_010092407.1
Coordinates 1766650..1766913 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM29_RS08065 1762238..1764484 + 2247 WP_080487064.1 TonB-dependent siderophore receptor -
WM29_RS08070 1764570..1765427 + 858 WP_069237010.1 N(5)-hydroxyornithine transformylase PvdF -
WM29_RS08075 1765427..1766437 + 1011 WP_059965046.1 acetyltransferase -
WM29_RS08080 1766650..1766913 + 264 WP_010092407.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WM29_RS08085 1766910..1767326 + 417 WP_059965048.1 PIN domain-containing protein Toxin
WM29_RS08090 1767460..1768623 + 1164 WP_059965049.1 amidohydrolase -
WM29_RS33225 1768692..1768937 + 246 WP_080002530.1 type II toxin-antitoxin system ParD family antitoxin -
WM29_RS08095 1769030..1770334 - 1305 WP_069237011.1 cobyrinate a,c-diamide synthase -
WM29_RS08100 1770338..1770940 - 603 WP_010092402.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
WM29_RS08105 1770969..1771346 - 378 WP_069237012.1 cobalamin biosynthesis protein -
WM29_RS08110 1771343..1772116 - 774 WP_060306474.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14619.75 Da        Isoelectric Point: 7.9093

>T58713 WP_059965048.1 NZ_CP013463:1766910-1767326 [Burkholderia ubonensis]
VTKLYMLDTNICSYIMRERPPVVLSRLQSCVGAQHRIVVSAVTYAEMRFGAIGRKASPKHADLVTAFVARLDGVLPWDAA
AVDATTAVRAGLAARGTPIGANDASIAGHAIAAGAVLVTHNTREFGRVDGLSFEDWAD

Download         Length: 417 bp

>T58713 NZ_CP013463:1766910-1767326 [Burkholderia ubonensis]
GTGACGAAGCTCTACATGCTCGATACGAACATCTGCTCGTACATCATGCGGGAGCGGCCGCCGGTCGTCCTGTCGCGGCT
GCAGTCGTGCGTCGGCGCGCAGCACCGGATCGTCGTGTCGGCCGTTACCTATGCGGAGATGCGCTTCGGCGCGATCGGCC
GGAAGGCGTCGCCGAAGCATGCCGACCTCGTGACCGCATTCGTCGCGCGGCTGGACGGCGTGCTGCCCTGGGACGCGGCG
GCCGTCGACGCGACGACCGCCGTGCGCGCCGGGCTCGCGGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
GGGGCACGCGATCGCGGCCGGCGCGGTGCTGGTGACTCACAACACGCGCGAATTCGGCCGCGTCGACGGGTTGTCGTTCG
AGGATTGGGCCGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9823.05 Da        Isoelectric Point: 4.6677

>AT58713 WP_010092407.1 NZ_CP013463:1766650-1766913 [Burkholderia ubonensis]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSLAHEPLADADFLVERPAVVESGRFDLSGPDD
AQTESGR

Download         Length: 264 bp

>AT58713 NZ_CP013463:1766650-1766913 [Burkholderia ubonensis]
ATGCGCACCGTTTCCATTTTCAAGAATGCCCGCAATCAGGCGATCCGCATCCCGAAGGACATGGAGTTCGAAGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACCCTGCTGCTTCGCCCCGTGCGTCCCACCTGGACGTCGCTCGCGCACGAGC
CGCTGGCGGATGCCGATTTCCTCGTCGAGCGCCCGGCCGTCGTCGAATCCGGCCGTTTCGACCTGTCCGGCCCCGACGAT
GCGCAAACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A105INJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A118MA44

References