Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1665681..1667428 Replicon chromosome
Accession NZ_CP013458
Organism Burkholderia sp. MSMB617WGS

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4SHE2
Locus tag WT60_RS28035 Protein ID WP_060356574.1
Coordinates 1666532..1667428 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4SHD2
Locus tag WT60_RS28030 Protein ID WP_038744096.1
Coordinates 1665681..1666535 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT60_RS28010 1660901..1662391 - 1491 WP_060356573.1 aldehyde dehydrogenase -
WT60_RS28015 1662413..1663228 - 816 WP_038744102.1 aspartate dehydrogenase -
WT60_RS28020 1663221..1664894 - 1674 WP_059582509.1 thiamine pyrophosphate-binding protein -
WT60_RS28025 1664887..1665684 - 798 WP_038744098.1 SDR family oxidoreductase -
WT60_RS28030 1665681..1666535 - 855 WP_038744096.1 IclR family transcriptional regulator Antitoxin
WT60_RS28035 1666532..1667428 - 897 WP_060356574.1 alpha/beta fold hydrolase Toxin
WT60_RS28040 1667445..1667972 - 528 WP_038744200.1 cupin domain-containing protein -
WT60_RS28045 1668004..1668774 - 771 WP_038744092.1 SDR family oxidoreductase -
WT60_RS28050 1668771..1669838 - 1068 WP_060356575.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WT60_RS28055 1669873..1670184 - 312 WP_038744087.1 hypothetical protein -
WT60_RS28060 1670186..1670503 - 318 WP_038744084.1 non-heme iron oxygenase ferredoxin subunit -
WT60_RS28070 1670938..1672026 + 1089 WP_038744082.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-281)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30360.29 Da        Isoelectric Point: 7.3656

>T58712 WP_060356574.1 NZ_CP013458:c1667428-1666532 [Burkholderia sp. MSMB617WGS]
MSAISTPAGDASAKPFAELLGCFAERRADAGAAGTIGYREAGDAHGERCPVVLLHGIGSGAASWVRQLDALGATRRVLAW
DAPGYGASSRVAADSPVAADYAAALGAWLDALRIGRCVLVGHSLGAIVAGAFARRAGERLSGLLLISPAGGYGSAPADVR
AERRDSRLALLAALGPQGLADERSANMLSAYASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLSHYHGRIAVAAG
ANDAITPPAACERIAQAAGVGLQVIPRVGHAGYVEAPDAYSALIDAFCRQCDGSRGAP

Download         Length: 897 bp

>T58712 NZ_CP013458:c1667428-1666532 [Burkholderia sp. MSMB617WGS]
ATGAGCGCAATTTCCACGCCGGCTGGCGACGCCAGCGCGAAACCGTTCGCGGAGCTGCTCGGCTGCTTTGCCGAGCGCCG
CGCGGACGCGGGCGCCGCGGGCACGATCGGCTACCGCGAGGCGGGCGACGCGCACGGCGAGCGCTGTCCCGTCGTGTTGC
TGCACGGGATCGGATCGGGCGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGCCGCGTGCTCGCGTGG
GATGCGCCCGGCTATGGTGCTTCGTCGCGCGTCGCGGCCGATTCGCCCGTCGCGGCCGATTACGCGGCGGCGCTCGGCGC
ATGGCTCGATGCGTTGCGGATCGGGCGCTGCGTGCTTGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGCGTTCGCGC
GGCGCGCGGGCGAGCGTCTGTCAGGATTGCTGCTGATTTCACCCGCGGGCGGCTACGGCAGCGCGCCCGCCGACGTGCGC
GCCGAGCGGCGCGACAGCCGGCTCGCGCTGCTCGCGGCGCTCGGCCCGCAAGGGCTCGCCGACGAGCGCAGCGCGAACAT
GCTGTCCGCGTACGCGAGCGACGCGGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCGGGCTATGCGC
AGGCGACGCACCTGCTCGCGAACGCGGACCTCGCGTCCGATCTTTCGCATTATCACGGCCGCATCGCGGTCGCGGCCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCACAGGCGGCGGGCGTCGGGTTGCAGGTGATTCCGCG
CGTGGGCCACGCGGGCTATGTCGAAGCGCCCGATGCGTACAGCGCGTTGATCGACGCATTTTGCCGTCAATGCGACGGAT
CGCGAGGTGCGCCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31263.70 Da        Isoelectric Point: 6.6619

>AT58712 WP_038744096.1 NZ_CP013458:c1666535-1665681 [Burkholderia sp. MSMB617WGS]
MSEPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETLDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNDARKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT58712 NZ_CP013458:c1666535-1665681 [Burkholderia sp. MSMB617WGS]
ATGAGCGAGCCGCTGCTGAAAGACGCCGACGACGCGAAGAATGATTCGAACTACGTAGTACCTGGGCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGTGCGCCCGAGCTGTCGAAGCGGCTCGGCATCCCGCGCA
CGACGGTGTTCCGCTTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGGGTTGCGGTGCTGCGCCTCGGCTTCGAGTATCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAGG
GCTGCGCGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCATGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTGTCGCTCGCCGAGTTGCGCGCGCTGTACCCCGAACGGGAGCTCGAGCGCGTGACGAAGGCGACGCC
GGAAACCCTCGACGCGCTCTTCGACGTGATTCGCGACGACGCGCGCCGCGGCTACGGGATCGGCAATTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACCGCGCCCGTGCGCAACGACGCGAGGAAGATCGTCGCGGTCGTCACGGTGACGGTGCCGAGG
CCCGAGATCGACGCATCGCTCGTCGCCGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGCTGTCGCGGCGGCT
CAACTACCGTTCCGACGACGAAAACACCTATTTGAAGGCTTTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4SHE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4SHD2

References