Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1434661..1435316 Replicon chromosome
Accession NZ_CP013458
Organism Burkholderia sp. MSMB617WGS

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag WT60_RS26955 Protein ID WP_006027262.1
Coordinates 1435020..1435316 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B4SGW8
Locus tag WT60_RS26950 Protein ID WP_060356650.1
Coordinates 1434661..1435017 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT60_RS26930 1429795..1430808 - 1014 WP_060356647.1 phage major capsid protein, P2 family -
WT60_RS26935 1430842..1431651 - 810 WP_060356648.1 GPO family capsid scaffolding protein -
WT60_RS26940 1431796..1433565 + 1770 WP_060356663.1 terminase ATPase subunit family protein -
WT60_RS26945 1433562..1434617 + 1056 WP_060356649.1 phage portal protein -
WT60_RS26950 1434661..1435017 - 357 WP_060356650.1 putative addiction module antidote protein Antitoxin
WT60_RS26955 1435020..1435316 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WT60_RS26960 1435962..1437077 - 1116 WP_059641242.1 DUF3396 domain-containing protein -
WT60_RS26965 1437092..1437829 - 738 WP_060356651.1 VRR-NUC domain-containing protein -
WT60_RS26970 1437826..1438359 - 534 WP_006027265.1 PAAR domain-containing protein -
WT60_RS26975 1438462..1438584 - 123 WP_009914987.1 hypothetical protein -
WT60_RS26980 1438818..1439471 - 654 WP_009914986.1 AAA family ATPase -
WT60_RS26985 1439561..1439767 - 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
WT60_RS26990 1439764..1440030 - 267 WP_059641237.1 ogr/Delta-like zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1409441..1453117 43676


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T58711 WP_006027262.1 NZ_CP013458:c1435316-1435020 [Burkholderia sp. MSMB617WGS]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T58711 NZ_CP013458:c1435316-1435020 [Burkholderia sp. MSMB617WGS]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATCGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12613.47 Da        Isoelectric Point: 9.9470

>AT58711 WP_060356650.1 NZ_CP013458:c1435017-1434661 [Burkholderia sp. MSMB617WGS]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRVRSRVRTAAHA

Download         Length: 357 bp

>AT58711 NZ_CP013458:c1435017-1434661 [Burkholderia sp. MSMB617WGS]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAAGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAATCCGCGCCTGATTCAAGCCGCGCTTGGGAACGTTGCGAAGGCGCGCGGCATGACGGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTACCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGTACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4SGW8

References