Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 895246..897023 Replicon chromosome
Accession NZ_CP013458
Organism Burkholderia sp. MSMB617WGS

Toxin (Protein)


Gene name hipA Uniprot ID A0A1B4SFR6
Locus tag WT60_RS24390 Protein ID WP_059670530.1
Coordinates 895246..896598 (-) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1B4SFR7
Locus tag WT60_RS24395 Protein ID WP_059670531.1
Coordinates 896595..897023 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT60_RS24365 892135..893091 - 957 WP_038743765.1 agmatinase -
WT60_RS24370 893244..894158 + 915 WP_060356746.1 LysR family transcriptional regulator -
WT60_RS24380 894445..894888 + 444 WP_059576055.1 hypothetical protein -
WT60_RS24390 895246..896598 - 1353 WP_059670530.1 type II toxin-antitoxin system HipA family toxin Toxin
WT60_RS24395 896595..897023 - 429 WP_059670531.1 helix-turn-helix domain-containing protein Antitoxin
WT60_RS24405 897714..898550 - 837 WP_060356748.1 taurine dioxygenase -
WT60_RS24410 898702..898917 - 216 Protein_791 hypothetical protein -
WT60_RS24415 898913..899923 + 1011 WP_038743780.1 taurine ABC transporter substrate-binding protein -
WT60_RS24420 899944..900726 + 783 WP_059576046.1 ATP-binding cassette domain-containing protein -
WT60_RS24425 900729..901580 + 852 WP_060356749.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49998.95 Da        Isoelectric Point: 8.4888

>T58710 WP_059670530.1 NZ_CP013458:c896598-895246 [Burkholderia sp. MSMB617WGS]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSPFELLATLGRDCVGALQMLPPDEAPDDLERIRGRALADADIARLLRDITSAPQAGQHEPLDDLRLSI
AGAQEKTALLRHRGRWLLPDGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDEQKALVV
ERFDRRPSSDARWILRLPQEDMCQATGTSALDKYQADGGPGIEAIMDVLAGSEHAGDRHAFFASQIVFWLLAATDGHAKN
FSIAHLPGNRYRSTPLYDVLSAHPVIGRGANRLPAQRVRLAMGVRGKHVHYLIHQIQRRHWIAQGQRVGFAPAEVDDMID
ALTARTAGVIDEVSARLPRDFPMDVADATFSGMLRLNAKLAAETAARASR

Download         Length: 1353 bp

>T58710 NZ_CP013458:c896598-895246 [Burkholderia sp. MSMB617WGS]
GTGAGCGCCCGCCGCGCGCGCGCCACGCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCATGCGCG
CGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCCGATCCGCAGGGCCGCCCGCTATCGCTGTCATTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATCCGG
CGCCGCATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAAGCGCCGGACGATCTCGAACGCATCCGCGGCCGCGCGCTCGCCGATGCGGACA
TCGCGCGGCTGCTGCGCGATATCACATCCGCGCCGCAAGCCGGGCAGCACGAGCCGCTCGACGATCTGCGCCTGTCGATC
GCGGGTGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGCTGGCTGCTGCCCGACGGCAGCACGCCGACCACGCA
TATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAAAACGAATGGCTGTGCT
CGAAGATCGTCGCCGCGTACGGATTGCCGGTCGCGCATTGCGACATCGCGCACTTCGACGAGCAGAAGGCGCTCGTCGTC
GAGCGCTTCGACCGCAGGCCGTCGAGCGACGCGCGCTGGATTCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCGACGGG
CACGTCCGCGCTCGACAAATATCAGGCCGACGGCGGGCCCGGCATCGAGGCGATCATGGACGTGCTCGCCGGCTCCGAGC
ACGCGGGCGACCGCCACGCGTTCTTCGCGTCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAAT
TTCAGCATCGCGCATCTGCCCGGCAACCGCTATCGATCGACGCCGTTATACGACGTGCTGTCCGCGCATCCGGTGATCGG
CCGGGGGGCGAACCGCTTGCCGGCGCAGCGCGTGCGGCTCGCGATGGGCGTGCGCGGCAAGCACGTCCATTACCTGATCC
ATCAGATCCAGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGAGGTCGACGACATGATCGAC
GCGTTGACCGCGCGCACCGCAGGCGTCATCGACGAAGTGTCGGCCCGGCTGCCGCGCGATTTTCCGATGGACGTCGCCGA
TGCGACCTTCAGCGGGATGCTGCGCCTGAATGCGAAGCTCGCGGCCGAAACGGCGGCGCGGGCCTCGCGATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15442.96 Da        Isoelectric Point: 12.0874

>AT58710 WP_059670531.1 NZ_CP013458:c897023-896595 [Burkholderia sp. MSMB617WGS]
MAITIEHEIKTLDQLRPILRGFRKVAGLTQAMVASRLGVTQQTYAQFEANPASASVERLFKVLRVLNVELTLTYIHTASA
RPAAKQAIALPARKAAQASGSGRAAAKRPAPPASQSMPAPRAAERQPRPARKRAAPKKREDW

Download         Length: 429 bp

>AT58710 NZ_CP013458:c897023-896595 [Burkholderia sp. MSMB617WGS]
ATGGCCATCACCATCGAACACGAGATCAAGACGCTCGACCAACTGCGGCCCATCCTGCGCGGCTTCCGCAAGGTGGCCGG
GTTGACGCAGGCGATGGTCGCGAGCCGCCTCGGCGTCACGCAGCAGACGTATGCGCAATTCGAGGCGAATCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTTCTCAACGTCGAGCTCACGCTCACCTACATCCACACCGCTTCCGCC
AGGCCCGCCGCGAAGCAAGCCATCGCCTTGCCCGCGCGCAAGGCCGCGCAGGCTTCCGGAAGCGGGCGCGCCGCCGCCAA
GCGCCCGGCGCCGCCCGCGAGCCAATCGATGCCCGCCCCGCGCGCCGCCGAGCGCCAGCCCCGCCCCGCGCGCAAGCGCG
CCGCCCCGAAGAAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4SFR6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4SFR7

References