Detailed information of TA system TA058708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 381015..381673
• Replicon: chromosome
• Accession: NZ_CP013456
• Organism: Burkholderia vietnamiensis strain MSMB608WGS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WL96_RS26530
• Protein ID: WP_011880197.1
• Coordinates: 381015..381449 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B4LJE8
• Locus tag: WL96_RS26535
• Protein ID: WP_043292778.1
• Coordinates: 381446..381673 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WL96_RS26510	377147..377551	+	405	WP_126221107.1	hypothetical protein	-
WL96_RS26515	377648..379345	+	1698	WP_046424735.1	tyrosine-type recombinase/integrase	-
WL96_RS26520	379639..380172	-	534	WP_011880200.1	RES family NAD+ phosphorylase	-
WL96_RS26525	380169..380600	-	432	WP_011880199.1	hypothetical protein	-
WL96_RS26530	381015..381449	-	435	WP_011880197.1	PIN domain-containing protein	Toxin
WL96_RS26535	381446..381673	-	228	WP_043292778.1	hypothetical protein	Antitoxin
WL96_RS31710	382470..382616	+	147	Protein_324	transposase	-
WL96_RS26545	382750..384540	+	1791	WP_011880194.1	nitrite/sulfite reductase	-
WL96_RS26550	384537..384944	+	408	WP_011880193.1	DUF934 domain-containing protein	-
WL96_RS31715	385130..385838	+	709	Protein_327	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	359082..386043	26961

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (3-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15721.10 Da
• Isoelectric Point: 7.2342

>T58708 WP_011880197.1 NZ_CP013456:c381449-381015 [Burkholderia vietnamiensis]
VITYLLDVNVLIALLDPAHVQHEPAHAWFGRVGHSAWATCPLTENGVLRIIGNPKYPNTMVSPASVAPLVVQLRSHAGHT
FWSDDVSLLDEKHVDATRLLSSAQLTDTYLLALARAHKGKLATFDRRLVVDAVPNGGKHLELIP

Nucleotide

• Length: 435 bp

>T58708 NZ_CP013456:c381449-381015 [Burkholderia vietnamiensis]
GTGATTACCTACCTTCTCGACGTCAACGTACTCATTGCTTTGCTCGACCCGGCACACGTTCAACACGAGCCGGCGCATGC
GTGGTTTGGCCGGGTAGGCCATTCCGCATGGGCCACGTGCCCGCTCACCGAGAACGGCGTGCTTCGAATTATCGGCAATC
CGAAATACCCGAATACGATGGTCTCTCCTGCATCCGTTGCACCGCTTGTTGTGCAACTGCGGTCCCATGCTGGGCACACA
TTCTGGTCGGACGATGTGAGCCTGCTCGACGAAAAACACGTCGACGCCACCCGTTTACTGTCCTCCGCTCAACTGACCGA
CACTTACCTCCTCGCGCTCGCTCGCGCACACAAAGGCAAGTTGGCGACCTTCGATCGCCGCTTGGTCGTCGACGCGGTTC
CGAACGGCGGGAAGCATCTTGAACTGATTCCTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8080.14 Da
• Isoelectric Point: 8.9793

>AT58708 WP_043292778.1 NZ_CP013456:c381673-381446 [Burkholderia vietnamiensis]
MRTTIDIDDDVLAFARERAKPGTSIGKVISDLARAALQRGTTNQSSRNGLPLMPVSATARPVTLDTVNQLRDDSL

Nucleotide

• Length: 228 bp

>AT58708 NZ_CP013456:c381673-381446 [Burkholderia vietnamiensis]
ATGCGTACCACTATTGATATCGACGACGACGTCCTTGCCTTCGCGCGGGAGCGTGCAAAGCCCGGCACGAGTATCGGGAA
GGTCATTTCTGACCTCGCCCGTGCGGCCCTGCAGCGCGGAACAACGAACCAGTCGAGCCGAAACGGCTTGCCGTTGATGC
CGGTTTCCGCGACCGCCCGTCCGGTCACCCTTGATACCGTTAATCAACTTCGCGACGACTCGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4LJE8