Detailed information of TA system TA058707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 379639..380600
• Replicon: chromosome
• Accession: NZ_CP013456
• Organism: Burkholderia vietnamiensis strain MSMB608WGS

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A1B4LHJ3
• Locus tag: WL96_RS26520
• Protein ID: WP_011880200.1
• Coordinates: 379639..380172 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A1B4LHE0
• Locus tag: WL96_RS26525
• Protein ID: WP_011880199.1
• Coordinates: 380169..380600 (-)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WL96_RS26505	375587..377020	+	1434	WP_126221193.1	TolC family protein	-
WL96_RS26510	377147..377551	+	405	WP_126221107.1	hypothetical protein	-
WL96_RS26515	377648..379345	+	1698	WP_046424735.1	tyrosine-type recombinase/integrase	-
WL96_RS26520	379639..380172	-	534	WP_011880200.1	RES family NAD+ phosphorylase	Toxin
WL96_RS26525	380169..380600	-	432	WP_011880199.1	hypothetical protein	Antitoxin
WL96_RS26530	381015..381449	-	435	WP_011880197.1	PIN domain-containing protein	-
WL96_RS26535	381446..381673	-	228	WP_043292778.1	hypothetical protein	-
WL96_RS31710	382470..382616	+	147	Protein_324	transposase	-
WL96_RS26545	382750..384540	+	1791	WP_011880194.1	nitrite/sulfite reductase	-
WL96_RS26550	384537..384944	+	408	WP_011880193.1	DUF934 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	359082..386043	26961

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-168)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 19147.77 Da
• Isoelectric Point: 5.1857

>T58707 WP_011880200.1 NZ_CP013456:c380172-379639 [Burkholderia vietnamiensis]
MILKPLQDIIAYRMHQPKWAVAPTSGAGAAKAGGRANRVGTPALYLALEVATAVAEYQQLSPLLPPGTLVSYRVTAAPVV
DFTAGFRGDHWSPLWESFFCDWRRDWFNKRIEPPSWVLGDEVIAAGAKGILFSSTQAAGGTNLVLFVDQLDNTDRLEVID
PAGALPRDQASWGESPA

Nucleotide

• Length: 534 bp

>T58707 NZ_CP013456:c380172-379639 [Burkholderia vietnamiensis]
ATGATCCTCAAGCCACTGCAGGACATCATCGCGTACCGGATGCACCAGCCCAAATGGGCGGTCGCGCCCACCAGTGGCGC
CGGGGCAGCGAAGGCAGGCGGGCGGGCGAACCGGGTCGGCACGCCGGCTTTGTACCTAGCCCTCGAAGTGGCTACCGCGG
TGGCCGAGTATCAGCAGCTGTCGCCGCTGCTACCGCCTGGCACGCTCGTGAGCTATCGCGTGACGGCCGCGCCCGTCGTT
GATTTCACGGCGGGCTTTCGTGGTGACCACTGGTCGCCATTGTGGGAGTCGTTCTTCTGCGACTGGCGCCGTGACTGGTT
CAACAAGCGGATCGAGCCACCAAGCTGGGTGCTAGGCGATGAGGTGATTGCCGCCGGCGCCAAAGGCATCCTGTTTTCGT
CAACGCAGGCAGCCGGCGGCACGAACCTGGTGCTGTTCGTTGACCAACTGGACAACACCGATCGCCTGGAGGTTATCGAT
CCAGCGGGCGCCTTGCCGCGCGATCAGGCCTCGTGGGGCGAGTCTCCCGCTTGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15299.19 Da
• Isoelectric Point: 5.6277

>AT58707 WP_011880199.1 NZ_CP013456:c380600-380169 [Burkholderia vietnamiensis]
MNTLATPSPAASAATPTGAAPVSFEAFLSSLREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPESASVQHF
LREAIRVIRAATDLSGDVYRALFWYRNEPLAVFDYQTAETLVSAGRAEDVLRYIVSLEAGAAG

Nucleotide

• Length: 432 bp

>AT58707 NZ_CP013456:c380600-380169 [Burkholderia vietnamiensis]
ATGAACACCCTCGCGACCCCCAGCCCAGCGGCGTCTGCGGCGACGCCCACCGGTGCGGCACCCGTCAGCTTCGAGGCCTT
TCTCAGCTCGCTACGGGAACCCGACACGGCAGCACCCGTGCTGTCGGCACGACGCTATGTGGCGGCCCTGAACATCGATC
TGCAGACGCTGGCCGACCAGGCGCATGTTCACCGAAACACCGTGGCGCGAGCCCCGGAGTCGGCATCGGTTCAGCACTTC
CTGCGCGAAGCGATCCGCGTGATTCGCGCCGCGACCGACCTGTCCGGTGACGTGTACCGCGCGTTGTTCTGGTACCGCAA
CGAGCCGCTGGCGGTGTTCGATTACCAGACAGCCGAAACGCTGGTTTCCGCCGGCCGGGCCGAGGACGTGCTGCGCTACA
TCGTGTCGCTGGAAGCGGGCGCGGCCGGATGA

Structures

Toxin

• AlphaFold DB: A0A1B4LHJ3

Antitoxin

• AlphaFold DB: A0A1B4LHE0