Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 150912..151555 Replicon chromosome
Accession NZ_CP013453
Organism Burkholderia vietnamiensis strain MSMB608WGS

Toxin (Protein)


Gene name vapC Uniprot ID I2DIN1
Locus tag WL96_RS00650 Protein ID WP_014722201.1
Coordinates 151154..151555 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1G5N4D1
Locus tag WL96_RS00645 Protein ID WP_034192974.1
Coordinates 150912..151154 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WL96_RS00630 146508..147542 + 1035 WP_011882843.1 helix-turn-helix domain-containing protein -
WL96_RS00635 147812..148933 - 1122 WP_011882844.1 hypothetical protein -
WL96_RS00640 148930..150633 - 1704 WP_069223984.1 thiamine pyrophosphate-binding protein -
WL96_RS00645 150912..151154 + 243 WP_034192974.1 AbrB family transcriptional regulator Antitoxin
WL96_RS00650 151154..151555 + 402 WP_014722201.1 type II toxin-antitoxin system VapC family toxin Toxin
WL96_RS00655 151623..153011 - 1389 WP_014722202.1 L-serine ammonia-lyase -
WL96_RS00660 153042..154178 - 1137 WP_045578623.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14908.05 Da        Isoelectric Point: 5.1684

>T58705 WP_014722201.1 NZ_CP013453:151154-151555 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Download         Length: 402 bp

>T58705 NZ_CP013453:151154-151555 [Burkholderia vietnamiensis]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTATGCCGAGCTGGAGTACGGCGTCACCGCTTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCCGTGCGTGACGCAACGCGCGCATGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAATGACGAGCGCGATTTCACGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9210.44 Da        Isoelectric Point: 5.7303

>AT58705 WP_034192974.1 NZ_CP013453:150912-151154 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIEIECIGDEIRIRPARRPLTQVLKKFAKFAPDFMAEGRGDHEQAEREGL

Download         Length: 243 bp

>AT58705 NZ_CP013453:150912-151154 [Burkholderia vietnamiensis]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGATCGAGTGCATCGGCGACGAGATCCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGC
TCAAGAAGTTCGCGAAGTTCGCGCCCGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2DIN1

Antitoxin

Source ID Structure
AlphaFold DB A0A1G5N4D1

References