Detailed information of TA system TA058702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1723127..1723766
• Replicon: chromosome
• Accession: NZ_CP013452
• Organism: Burkholderia cenocepacia strain MSMB384WGS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WL90_RS29025
• Protein ID: WP_179148689.1
• Coordinates: 1723127..1723543 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: WL90_RS29030
• Protein ID: WP_006481537.1
• Coordinates: 1723530..1723766 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WL90_RS29000	1718234..1719334	-	1101	WP_034202287.1	nitronate monooxygenase	-
WL90_RS29005	1719331..1720251	-	921	WP_006481536.1	enoyl-CoA hydratase	-
WL90_RS29010	1720260..1721057	-	798	WP_060263976.1	hypothetical protein	-
WL90_RS29015	1721068..1721961	-	894	WP_043204678.1	CoA transferase subunit A	-
WL90_RS29020	1721971..1722867	-	897	WP_058903174.1	VOC family protein	-
WL90_RS29025	1723127..1723543	-	417	WP_179148689.1	type II toxin-antitoxin system VapC family toxin	Toxin
WL90_RS29030	1723530..1723766	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
WL90_RS29035	1724259..1725485	+	1227	WP_034202283.1	acyltransferase	-
WL90_RS29040	1725496..1726173	-	678	WP_077176171.1	hypothetical protein	-
WL90_RS29045	1726822..1727595	-	774	WP_058903177.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15401.65 Da
• Isoelectric Point: 7.4038

>T58702 WP_179148689.1 NZ_CP013452:c1723543-1723127 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEANASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T58702 NZ_CP013452:c1723543-1723127 [Burkholderia cenocepacia]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGAGGGCGTTCTTCAG
GCAGGCCGAAGCCAACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCTTGGCTCACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGTTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT58702 WP_006481537.1 NZ_CP013452:c1723766-1723530 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT58702 NZ_CP013452:c1723766-1723530 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGTGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554