Detailed information of TA system TA058701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1206438..1207084
• Replicon: chromosome
• Accession: NZ_CP013452
• Organism: Burkholderia cenocepacia strain MSMB384WGS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B4EGU9
• Locus tag: WL90_RS26795
• Protein ID: WP_006491144.1
• Coordinates: 1206677..1207084 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B4EGU8
• Locus tag: WL90_RS26790
• Protein ID: WP_006491146.1
• Coordinates: 1206438..1206680 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WL90_RS26775	1202433..1203839	+	1407	WP_006491136.1	aspartate ammonia-lyase	-
WL90_RS26780	1203917..1205422	+	1506	WP_006491141.1	amino acid permease	-
WL90_RS26785	1205496..1206179	-	684	WP_060265695.1	phospholipase	-
WL90_RS26790	1206438..1206680	+	243	WP_006491146.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WL90_RS26795	1206677..1207084	+	408	WP_006491144.1	type II toxin-antitoxin system VapC family toxin	Toxin
WL90_RS36400	1207201..1207428	-	228	WP_006491154.1	hypothetical protein	-
WL90_RS26800	1207486..1209861	+	2376	WP_060214847.1	MCP four helix bundle domain-containing protein	-
WL90_RS26805	1209884..1210612	+	729	WP_060266112.1	chemotaxis protein	-
WL90_RS26810	1210609..1211190	+	582	WP_058902967.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14822.93 Da
• Isoelectric Point: 6.2165

>T58701 WP_006491144.1 NZ_CP013452:1206677-1207084 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHALYYGAYKSQRAAANVARVEALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPSAD

Nucleotide

• Length: 408 bp

>T58701 NZ_CP013452:1206677-1207084 [Burkholderia cenocepacia]
ATGAAGTTCCTGCTGGATACCAACGCGGTGATCGCCATTCTCAAAGGCGAGCCGGCGATACTGGCCCGTTTGCATGCCTG
GCACCCGGCCGATTTCGGGATCCCCGCGATCGTCGCGCACGCGCTTTACTACGGCGCGTACAAGAGCCAGCGAGCGGCGG
CGAACGTCGCGCGTGTCGAGGCGTTGCAGTTCGAGGTCGTATCATTCGACACCGAGGATGCACAGCATGCGGGTGAAATT
CGCGCGCACCTGATCGCGGCCGGCACGCCGATTGGTCCATACGACGCCTTGATCGCAGGGCAGGCGCGCGCGCGGCAACT
GGTGCTGGTCACGCACAACGTCCGCGAATTCGAGCGCGTTCCGCGGCTGCAATTCGAAGACTGGCTAGCCGAACCGAGCG
CAGACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.02 Da
• Isoelectric Point: 5.0197

>AT58701 WP_006491146.1 NZ_CP013452:1206438-1206680 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Nucleotide

• Length: 243 bp

>AT58701 NZ_CP013452:1206438-1206680 [Burkholderia cenocepacia]
ATGGATACTGCAAAGCTCTTCAAGCATGGCGGCTCGCAGGCTGTCCGGCTGCCGAAGGATTTCCGCTTCGATACGGCCGA
GGTTCGCATCCGCCGCCACGGGGCGGCCGTCATTCTCGAGCCGATGCCGCAAGACTGGGCTTGGCTGGCACCGCTGATCG
GTCCGGTGGACGCCGATTTCGAGGCTGCCGCGACCACACAGCCGTCCGCTCAGGAGCGCTCGGGCCTGGACGTGTTCGAA
TGA

Structures

Toxin

• AlphaFold DB: B4EGU9

Antitoxin

• AlphaFold DB: B4EGU8