Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 832782..833402 Replicon chromosome
Accession NZ_CP013452
Organism Burkholderia cenocepacia strain MSMB384WGS

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag WL90_RS25175 Protein ID WP_059722545.1
Coordinates 833085..833402 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag WL90_RS25170 Protein ID WP_006490972.1
Coordinates 832782..833081 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WL90_RS25145 828015..829286 + 1272 WP_058902844.1 Rieske 2Fe-2S domain-containing protein -
WL90_RS25150 829302..829778 + 477 WP_006490977.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WL90_RS25155 829814..830140 + 327 WP_006496019.1 non-heme iron oxygenase ferredoxin subunit -
WL90_RS25160 830130..831350 + 1221 WP_058902845.1 FAD-dependent oxidoreductase -
WL90_RS25165 831447..832733 + 1287 WP_006490986.1 DUF445 domain-containing protein -
WL90_RS25170 832782..833081 - 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
WL90_RS25175 833085..833402 - 318 WP_059722545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WL90_RS25180 833791..835431 + 1641 WP_006490980.1 acetolactate synthase large subunit -
WL90_RS25185 835460..836893 + 1434 WP_060268376.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11739.43 Da        Isoelectric Point: 8.0598

>T58700 WP_059722545.1 NZ_CP013452:c833402-833085 [Burkholderia cenocepacia]
MPYSPPAFSIRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRGTIWVILL
CGGDQSAQQADIRAAHAMLAHLDME

Download         Length: 318 bp

>T58700 NZ_CP013452:c833402-833085 [Burkholderia cenocepacia]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCT
CGCCAAACGCCGCATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGCCCGGGCTATCGCGTCTATGACGTGAGGCGCGGAACGATATGGGTCATCCTGCTC
TGCGGCGGCGATCAATCGGCGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT58700 WP_006490972.1 NZ_CP013452:c833081-832782 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp

>AT58700 NZ_CP013452:c833081-832782 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGCGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References