Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1858258..1858792 Replicon chromosome
Accession NZ_CP013450
Organism Burkholderia cenocepacia strain MSMB384WGS

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag WL90_RS08550 Protein ID WP_021033200.1
Coordinates 1858493..1858792 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag WL90_RS08545 Protein ID WP_021033199.1
Coordinates 1858258..1858503 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WL90_RS08530 1854967..1855806 + 840 WP_034201792.1 N(5)-hydroxyornithine transformylase PvdF -
WL90_RS08535 1855806..1856822 + 1017 WP_048986709.1 acetyltransferase -
WL90_RS08540 1856980..1858143 + 1164 WP_006486051.1 amidohydrolase -
WL90_RS08545 1858258..1858503 + 246 WP_021033199.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
WL90_RS08550 1858493..1858792 + 300 WP_021033200.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WL90_RS08555 1858883..1860187 - 1305 WP_060268065.1 cobyrinate a,c-diamide synthase -
WL90_RS08560 1860190..1860792 - 603 WP_006476035.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
WL90_RS08565 1860828..1861205 - 378 WP_006496449.1 cobalamin biosynthesis protein -
WL90_RS08570 1861202..1861951 - 750 WP_058902267.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11720.37 Da        Isoelectric Point: 6.9677

>T58699 WP_021033200.1 NZ_CP013450:1858493-1858792 [Burkholderia cenocepacia]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T58699 NZ_CP013450:1858493-1858792 [Burkholderia cenocepacia]
ATGGCGGTTAAAGGCAGACAACTTCGGCTGACCCCGTTGGCTGAATGCGATCTTGAAGACATTTGGCGCTATACCGCCGA
GCATTGGTCGCCTGAGCAGGCAGAGCACTATTACCGCGATCTGATTGGCACCATGGAAGCGCTGGCGCGCGGCAAAAAAG
CGGGGCGGATTTGCGTTGTTCGCGACGGATATTTTCGCTACCCCGCTGGTTCTCACGTTGTGTTCTATCGCGAAACGGAT
GAAACCATCGACGTCATCCGTGTCCTGCATCAACGGATGGACATCGAACGACATCTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.68 Da        Isoelectric Point: 7.3196

>AT58699 WP_021033199.1 NZ_CP013450:1858258-1858503 [Burkholderia cenocepacia]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT58699 NZ_CP013450:1858258-1858503 [Burkholderia cenocepacia]
ATGTCGCGAAACACATCCGTTTCCCTTGGCGATCACTTTGCAGAATTTGTCGATGCGCAGGTGCGATCGGGACGATATGG
TTCCGCAAGTGACGTCGTGCGAGCCGGGTTGCGGCTCCTCGAATCACACGAAACGCAAATGCGTGCATTGCAGGAAGCAT
TGAAGGCGGGTGAAGGGTCGGGGACGCCCAAGCCCTTCGACAGCGAGGCCTTCCTGGCCCGCATGCGGGCCACGCATGGC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References