Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 3254480..3254999 Replicon chromosome
Accession NZ_CP013447
Organism Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)


Gene name stbE Uniprot ID A0A1B4Q3L5
Locus tag WK67_RS34005 Protein ID WP_069271744.1
Coordinates 3254480..3254761 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B4Q3L2
Locus tag WK67_RS34010 Protein ID WP_069271745.1
Coordinates 3254751..3254999 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK67_RS33990 3250994..3252103 + 1110 WP_069271742.1 AGE family epimerase/isomerase -
WK67_RS33995 3252076..3253692 - 1617 WP_069271743.1 Tar ligand binding domain-containing protein -
WK67_RS34000 3253927..3254370 + 444 WP_010090127.1 PaaI family thioesterase -
WK67_RS34005 3254480..3254761 - 282 WP_069271744.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WK67_RS34010 3254751..3254999 - 249 WP_069271745.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WK67_RS34015 3255118..3256179 - 1062 WP_069271934.1 CoA transferase -
WK67_RS34020 3256304..3257494 - 1191 WP_045564108.1 2-methylaconitate cis-trans isomerase PrpF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11009.82 Da        Isoelectric Point: 10.7817

>T58697 WP_069271744.1 NZ_CP013447:c3254761-3254480 [Burkholderia ubonensis]
MTFELAFLEPALREWKRFDRTVRDQFKSKLAERLENPRIPSAKPHGHPDRYKIKLRSAGYRLVYEVRDTEVIVLVVAVGR
RERDAVYLAALKR

Download         Length: 282 bp

>T58697 NZ_CP013447:c3254761-3254480 [Burkholderia ubonensis]
ATGACCTTTGAACTCGCATTTCTCGAACCTGCATTGAGAGAGTGGAAGAGGTTTGATCGCACCGTTCGCGACCAGTTCAA
ATCCAAACTCGCCGAGCGGCTTGAAAACCCTCGCATCCCCTCGGCAAAGCCGCACGGCCACCCGGATCGCTACAAGATCA
AGCTACGCAGCGCCGGCTACCGACTTGTCTACGAAGTGCGCGACACGGAGGTCATCGTGCTGGTTGTCGCAGTCGGCCGG
CGCGAACGCGATGCAGTCTATCTTGCCGCGCTGAAACGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8873.19 Da        Isoelectric Point: 5.0636

>AT58697 WP_069271745.1 NZ_CP013447:c3254999-3254751 [Burkholderia ubonensis]
MPHTILASVTASVSELKRNPMGTVAAGEGSPVAILNHNEPAFYCIPAKTWEAMLERLEDIEDNALADARAKEKAVKVKLN
DL

Download         Length: 249 bp

>AT58697 NZ_CP013447:c3254999-3254751 [Burkholderia ubonensis]
ATGCCTCACACCATCCTGGCAAGCGTTACGGCGAGCGTCTCCGAGCTGAAGCGGAACCCGATGGGAACCGTTGCGGCGGG
AGAGGGTTCCCCGGTGGCGATCCTGAACCACAACGAACCGGCGTTCTATTGCATCCCTGCGAAGACCTGGGAGGCGATGC
TCGAACGTCTGGAGGATATCGAAGACAACGCGCTGGCTGATGCGCGTGCCAAGGAGAAGGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4Q3L5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4Q3L2

References