Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2638999..2640235 | Replicon | chromosome |
| Accession | NZ_CP013447 | ||
| Organism | Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A125CIL1 |
| Locus tag | WK67_RS31370 | Protein ID | WP_059654575.1 |
| Coordinates | 2639654..2640235 (+) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | WK67_RS31365 | Protein ID | WP_059851707.1 |
| Coordinates | 2638999..2639556 (+) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WK67_RS31340 | 2634217..2634939 | - | 723 | WP_069274766.1 | hypothetical protein | - |
| WK67_RS37850 | 2634938..2635171 | + | 234 | WP_155123272.1 | hypothetical protein | - |
| WK67_RS31350 | 2635637..2636386 | - | 750 | WP_155123273.1 | hypothetical protein | - |
| WK67_RS36685 | 2636621..2637099 | + | 479 | Protein_2313 | isochorismatase family protein | - |
| WK67_RS31355 | 2637263..2637679 | - | 417 | WP_045563786.1 | hypothetical protein | - |
| WK67_RS31360 | 2638012..2638743 | - | 732 | WP_059718987.1 | ribonuclease T2 | - |
| WK67_RS31365 | 2638999..2639556 | + | 558 | WP_059851707.1 | helix-turn-helix domain-containing protein | Antitoxin |
| WK67_RS31370 | 2639654..2640235 | + | 582 | WP_059654575.1 | HD domain-containing protein | Toxin |
| WK67_RS31375 | 2640390..2641580 | + | 1191 | WP_069271564.1 | macrolide transporter subunit MacA | - |
| WK67_RS31380 | 2641583..2643622 | + | 2040 | WP_060153958.1 | MacB family efflux pump subunit | - |
| WK67_RS31385 | 2643628..2645013 | + | 1386 | WP_069271565.1 | efflux transporter outer membrane subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21219.89 Da Isoelectric Point: 5.5340
>T58696 WP_059654575.1 NZ_CP013447:2639654-2640235 [Burkholderia ubonensis]
MTPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALDGVDPLKLLKLCVVHDLGEALHGDIP
AVEQAAHPDKSAHERRDLLTLTAGLDAALRDEIVALWDEYEQAASPEAKAVKALDKLETILQHNQGDNPPDFDYAFNLGY
GRRHTDASPLFRAIRAIVDADTQSRIDAGARRA
MTPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALDGVDPLKLLKLCVVHDLGEALHGDIP
AVEQAAHPDKSAHERRDLLTLTAGLDAALRDEIVALWDEYEQAASPEAKAVKALDKLETILQHNQGDNPPDFDYAFNLGY
GRRHTDASPLFRAIRAIVDADTQSRIDAGARRA
Download Length: 582 bp
>T58696 NZ_CP013447:2639654-2640235 [Burkholderia ubonensis]
ATGACTCCCGACACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCGGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCGCGGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTGGTGTTCGCCGACGCGC
TCGACGGCGTCGACCCGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCG
GCGGTCGAGCAGGCCGCGCATCCGGACAAGAGCGCGCACGAGCGGCGCGACCTGCTGACGCTGACCGCCGGCCTCGACGC
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGCAGGCCGCGTCGCCGGAAGCGAAGGCCGTCAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCGACAATCCGCCGGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCCATACGGACGCGAGCCCGCTGTTCCGCGCGATCCGGGCGATCGTCGACGCCGACACGCAAAGCCGGATCGA
CGCCGGCGCGCGGCGCGCGTGA
ATGACTCCCGACACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCGGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCGCGGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTGGTGTTCGCCGACGCGC
TCGACGGCGTCGACCCGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCG
GCGGTCGAGCAGGCCGCGCATCCGGACAAGAGCGCGCACGAGCGGCGCGACCTGCTGACGCTGACCGCCGGCCTCGACGC
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGCAGGCCGCGTCGCCGGAAGCGAAGGCCGTCAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCGACAATCCGCCGGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCCATACGGACGCGAGCCCGCTGTTCCGCGCGATCCGGGCGATCGTCGACGCCGACACGCAAAGCCGGATCGA
CGCCGGCGCGCGGCGCGCGTGA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20303.41 Da Isoelectric Point: 9.5082
>AT58696 WP_059851707.1 NZ_CP013447:2638999-2639556 [Burkholderia ubonensis]
MTDSPLQTPPLGPLLKRWRLLRRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERAIAERLLAARLDSAGDRALARLICD
HPGRVHLVCDLTHRLLACSSLRAAEFAKPLPTMLGASLWRYATPEIAALEASLDTLGWRDSAGPPSVEFDSGANASRIVP
IRRSTCRWTRMILSDGSAARLVETL
MTDSPLQTPPLGPLLKRWRLLRRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERAIAERLLAARLDSAGDRALARLICD
HPGRVHLVCDLTHRLLACSSLRAAEFAKPLPTMLGASLWRYATPEIAALEASLDTLGWRDSAGPPSVEFDSGANASRIVP
IRRSTCRWTRMILSDGSAARLVETL
Download Length: 558 bp
>AT58696 NZ_CP013447:2638999-2639556 [Burkholderia ubonensis]
ATGACCGACTCGCCGCTTCAAACGCCGCCGCTCGGCCCGCTGCTGAAGCGCTGGCGGCTCCTGCGCCGCGTCAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAGTCGACGATTTCCCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGATCGCCGAGCGCCTGCTCGCGGCGCGGCTCGATTCCGCCGGCGACCGCGCGCTCGCGCGGCTCATCTGCGAC
CATCCCGGCCGCGTGCACCTCGTGTGCGACCTCACGCATCGGCTGCTGGCGTGCTCGTCGTTGCGCGCCGCCGAGTTCGC
GAAACCGCTGCCGACGATGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCGCGCTGGAAGCGTCGCTCG
ACACGCTCGGCTGGCGCGACAGCGCCGGGCCGCCGAGCGTCGAGTTCGACAGCGGCGCGAACGCATCGCGCATCGTGCCG
ATCCGTCGCAGCACCTGCCGCTGGACGCGGATGATCCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTAG
ATGACCGACTCGCCGCTTCAAACGCCGCCGCTCGGCCCGCTGCTGAAGCGCTGGCGGCTCCTGCGCCGCGTCAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAGTCGACGATTTCCCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGATCGCCGAGCGCCTGCTCGCGGCGCGGCTCGATTCCGCCGGCGACCGCGCGCTCGCGCGGCTCATCTGCGAC
CATCCCGGCCGCGTGCACCTCGTGTGCGACCTCACGCATCGGCTGCTGGCGTGCTCGTCGTTGCGCGCCGCCGAGTTCGC
GAAACCGCTGCCGACGATGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCGCGCTGGAAGCGTCGCTCG
ACACGCTCGGCTGGCGCGACAGCGCCGGGCCGCCGAGCGTCGAGTTCGACAGCGGCGCGAACGCATCGCGCATCGTGCCG
ATCCGTCGCAGCACCTGCCGCTGGACGCGGATGATCCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|