Detailed information of TA system TA058694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1745353..1745992
• Replicon: chromosome
• Accession: NZ_CP013447
• Organism: Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WK67_RS27700
• Protein ID: WP_069271275.1
• Coordinates: 1745353..1745769 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A105LH90
• Locus tag: WK67_RS27705
• Protein ID: WP_010089470.1
• Coordinates: 1745756..1745992 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK67_RS36375	1742031..1742276	+	246	WP_080426120.1	hypothetical protein	-
WK67_RS27680	1742419..1742655	-	237	WP_059825823.1	hypothetical protein	-
WK67_RS27685	1742652..1743899	-	1248	WP_069271274.1	phosphoesterase	-
WK67_RS27690	1744116..1744382	-	267	WP_010089473.1	translation initiation factor IF-1	-
WK67_RS27695	1744894..1745097	-	204	WP_010089472.1	cold-shock protein	-
WK67_RS27700	1745353..1745769	-	417	WP_069271275.1	type II toxin-antitoxin system VapC family toxin	Toxin
WK67_RS27705	1745756..1745992	-	237	WP_010089470.1	hypothetical protein	Antitoxin
WK67_RS27710	1746117..1747244	-	1128	WP_059588734.1	VOC family protein	-
WK67_RS27715	1747595..1748902	+	1308	WP_060015959.1	shikimate transporter	-
WK67_RS27720	1749091..1750392	+	1302	WP_069271276.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
WK67_RS37665	1750635..1750775	+	141	WP_155123235.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1742250..2233065	490815

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15427.70 Da
• Isoelectric Point: 6.7291

>T58694 WP_069271275.1 NZ_CP013447:c1745769-1745353 [Burkholderia ubonensis]
MFLIDTNVVSEIRKGKRTNNGVRAFFRQAEADASALYLSVVTVSELRRGVEMIRHRGDVRQASTLEAWLETLLSDYAPNI
LPVDIEISQVWGMLRAPHPAHELDKLIAATALINDLTVVTRNVGDFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T58694 NZ_CP013447:c1745769-1745353 [Burkholderia ubonensis]
ATGTTTTTGATTGATACGAACGTCGTCAGCGAAATCAGAAAGGGAAAGCGAACCAACAATGGGGTGCGGGCATTCTTTCG
GCAAGCCGAAGCCGACGCGAGCGCCCTTTACCTGTCCGTCGTGACGGTGTCCGAGCTGCGGCGCGGCGTCGAGATGATCC
GTCATCGCGGCGACGTCCGGCAGGCGTCGACTCTCGAAGCGTGGCTGGAGACGCTCCTGTCCGACTATGCGCCGAACATC
CTGCCGGTCGATATCGAGATCAGCCAGGTGTGGGGGATGCTGCGCGCGCCCCATCCGGCGCACGAACTGGACAAGCTGAT
CGCAGCCACCGCGCTGATCAACGACCTGACGGTCGTGACCCGCAACGTCGGCGATTTCGCGAGAACCGGCGTGAGGCTGC
TGAATCCGTTCGACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8585.53 Da
• Isoelectric Point: 5.6088

>AT58694 WP_010089470.1 NZ_CP013447:c1745992-1745756 [Burkholderia ubonensis]
MANLLVRNVDDSIVQSLREQAAAHGRSAEAEHRAILASALARPKRKTFAEALKSIPDVGEDTDFERVQDSGEARHVFD

Nucleotide

• Length: 237 bp

>AT58694 NZ_CP013447:c1745992-1745756 [Burkholderia ubonensis]
ATGGCCAATCTACTGGTGCGTAACGTGGATGACAGCATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCGCACGGCCGGAG
TGCGGAGGCCGAGCACCGCGCCATTCTCGCGAGTGCGCTCGCCCGGCCGAAGCGCAAGACCTTCGCGGAAGCGCTGAAGA
GCATCCCCGATGTTGGCGAAGACACGGATTTCGAGCGCGTGCAGGATTCCGGCGAGGCCAGGCATGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A105LH90