58692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1281780..1283530 Replicon chromosome
Accession NZ_CP013447
Organism Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WK67_RS25855 Protein ID WP_069271124.1
Coordinates 1281780..1282682 (+) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A105U4R4
Locus tag WK67_RS25860 Protein ID WP_059526581.1
Coordinates 1282679..1283530 (+) Length 284 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK67_RS25825 1277181..1278260 - 1080 WP_069271122.1 porin -
WK67_RS25830 1278697..1279014 + 318 WP_017329029.1 non-heme iron oxygenase ferredoxin subunit -
WK67_RS25835 1279018..1279329 + 312 WP_042588193.1 hypothetical protein -
WK67_RS25840 1279374..1280444 + 1071 WP_069271123.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WK67_RS25845 1280437..1281207 + 771 WP_059659979.1 SDR family oxidoreductase -
WK67_RS25850 1281234..1281761 + 528 WP_010089663.1 cupin domain-containing protein -
WK67_RS25855 1281780..1282682 + 903 WP_069271124.1 alpha/beta fold hydrolase Toxin
WK67_RS25860 1282679..1283530 + 852 WP_059526581.1 IclR family transcriptional regulator Antitoxin
WK67_RS25865 1283530..1284327 + 798 WP_059526585.1 SDR family oxidoreductase -
WK67_RS25870 1284320..1285987 + 1668 WP_042588187.1 thiamine pyrophosphate-binding protein -
WK67_RS25875 1285980..1286813 + 834 WP_069271125.1 aspartate dehydrogenase -
WK67_RS25880 1286836..1288326 + 1491 WP_060075360.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-281)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 30907.13 Da        Isoelectric Point: 8.4940

>T58692 WP_069271124.1 NZ_CP013447:1281780-1282682 [Burkholderia ubonensis]
MSVIDKRERDRERIASFAALLERFPEQRSPAGAAGTIGYRAAGAQHAGRTLPVVLLHGIGSGAASWVRQLDALGASRRVF
AWDAPGYGASTPVHGASPAAADYAASLAAWLDAIGIDRCVLVGHSLGAIIAGGFARVMPERVAGLLLISPAGGYGSAPAE
TRASRRDARLAMLDELGPAGLAAQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVA
VGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDLQRGPA

Download         Length: 903 bp

>T58692 NZ_CP013447:1281780-1282682 [Burkholderia ubonensis]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCGAGCGCATCGCGAGCTTCGCAGCGCTGCTCGAGCGGTTTCCCGAGCA
GCGCTCGCCGGCCGGCGCGGCGGGCACGATCGGCTACCGCGCGGCCGGCGCGCAGCATGCGGGCCGCACGCTCCCCGTCG
TGCTGCTGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGATGCGCTCGGCGCTTCGCGGCGCGTGTTC
GCATGGGACGCGCCCGGCTACGGCGCGTCGACGCCGGTGCACGGCGCATCGCCGGCCGCAGCCGACTACGCGGCATCGCT
CGCCGCGTGGCTCGATGCGATCGGCATCGACCGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGCT
TCGCCCGCGTGATGCCGGAGCGCGTCGCCGGGCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCGGCCGAG
ACGCGTGCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGACGAACTCGGCCCTGCCGGGCTCGCGGCGCAGCGCAGCGG
CAACATGCTGTCCGGCTTTGCGAGCGAGGACGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCT
ACGCGCAGGCGACGCATCTGCTCGCGAACGCCGATCTCGCGTCGGACCTCGCGGGCTTTCGCGGCCGCACGGCGGTGGCC
GTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGGCGGCCGCGCACGTCGGGCTGCAGGTGAT
TCCGCAGGCCGGACATGCGGGCTACGTCGAGGCGCCGGCCGTCTATTCCGCACTGATCGACGCGTTCTGCCGTCAGTGCG
ACCTGCAGCGGGGGCCGGCATGA

Antitoxin


Download         Length: 284 a.a.        Molecular weight: 30930.38 Da        Isoelectric Point: 6.3562

>AT58692 WP_059526581.1 NZ_CP013447:1282679-1283530 [Burkholderia ubonensis]
MSEPLLNENDGAKGEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLGELRALYPEGTLQRMTQATPDTVDALYGVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGL

Download         Length: 852 bp

>AT58692 NZ_CP013447:1282679-1283530 [Burkholderia ubonensis]
ATGAGCGAACCGCTGCTGAATGAAAACGACGGCGCGAAGGGCGAAGCGAACTACGTGGTGCCGGGCCTCGAACGGGGCTT
GAGAATCCTCGCGGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGACGCGACCGGGTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
GCCAGGCGCCGGTGTTCAGCTCGATCCGGGTGAACGTCGGCACGCGGCTGCCCGCGCACGCGACCACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGGGCGAGCTGCGCGCGCTGTATCCGGAGGGCACGCTGCAGCGGATGACGCAGGCGACGCC
GGACACGGTCGACGCGCTGTACGGCGTGATCCGCGAGGATGCGTTGCGCGGCTACGGCGTCAGCAACTCGTCGTTCGAGC
GCGGCATCTCGGTCGTCACCGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGGCGCTGATTGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAACTATCGCTCGGACGACGAGCACACGTTTCTGAAGGCTTTGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A105U4R4

References