Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1798391..1799067 Replicon chromosome
Accession NZ_CP013446
Organism Burkholderia ubonensis strain MSMB1189WGS isolate MSMB1189WGS

Toxin (Protein)


Gene name vagD Uniprot ID A0A118HYA4
Locus tag WK67_RS11555 Protein ID WP_010092406.1
Coordinates 1798651..1799067 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A118MA44
Locus tag WK67_RS11550 Protein ID WP_010092407.1
Coordinates 1798391..1798654 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK67_RS11535 1793997..1796219 + 2223 WP_069270155.1 TonB-dependent siderophore receptor -
WK67_RS11540 1796305..1797162 + 858 WP_060137461.1 N(5)-hydroxyornithine transformylase PvdF -
WK67_RS11545 1797162..1798178 + 1017 WP_069270156.1 acetyltransferase -
WK67_RS11550 1798391..1798654 + 264 WP_010092407.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WK67_RS11555 1798651..1799067 + 417 WP_010092406.1 PIN domain-containing protein Toxin
WK67_RS11560 1799201..1800364 + 1164 WP_060071428.1 amidohydrolase -
WK67_RS11565 1800622..1801926 - 1305 WP_069270157.1 cobyrinate a,c-diamide synthase -
WK67_RS11570 1801930..1802532 - 603 WP_059827067.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
WK67_RS11575 1802561..1802938 - 378 WP_069270158.1 cobalamin biosynthesis protein -
WK67_RS11580 1802935..1803708 - 774 WP_069270159.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14691.81 Da        Isoelectric Point: 7.3224

>T58689 WP_010092406.1 NZ_CP013446:1798651-1799067 [Burkholderia ubonensis]
VTKLYMLDTNICSYIMRERPPVVLSRLQSCVGAQHRIVVSAVTYAEMRFGAIGRKASPKHADLVTAFVARLDGVLPWDAA
AVDATTAVRAELAARGTPIGANDASIAGHAIAAGAVLVTHNTREFGRVDGLSFEDWAD

Download         Length: 417 bp

>T58689 NZ_CP013446:1798651-1799067 [Burkholderia ubonensis]
GTGACGAAGCTCTACATGCTCGATACGAACATCTGCTCGTACATCATGCGGGAGCGGCCGCCGGTCGTCCTGTCGCGGCT
GCAGTCGTGCGTCGGCGCGCAGCACCGGATCGTCGTGTCGGCCGTGACCTATGCGGAGATGCGCTTCGGCGCGATCGGCC
GGAAGGCGTCGCCGAAGCATGCCGACCTCGTGACCGCATTCGTCGCGCGGCTGGACGGCGTGCTGCCCTGGGATGCGGCG
GCCGTCGACGCGACGACCGCCGTGCGCGCCGAGCTCGCGGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
GGGGCACGCGATCGCGGCCGGCGCGGTGCTGGTGACCCACAACACGCGCGAATTCGGCCGCGTCGACGGGTTGTCGTTCG
AGGATTGGGCCGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9823.05 Da        Isoelectric Point: 4.6677

>AT58689 WP_010092407.1 NZ_CP013446:1798391-1798654 [Burkholderia ubonensis]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSLAHEPLADADFLVERPAVVESGRFDLSGPDD
AQTESGR

Download         Length: 264 bp

>AT58689 NZ_CP013446:1798391-1798654 [Burkholderia ubonensis]
ATGCGCACCGTTTCCATTTTCAAGAATGCCCGCAATCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAAGGCGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACCCTGCTGCTTCGCCCGGTGCGTCCCACGTGGACGTCGCTCGCGCACGAGC
CGCTGGCGGATGCCGATTTCCTCGTCGAGCGCCCGGCCGTCGTCGAATCCGGCCGTTTCGACCTGTCCGGCCCCGACGAT
GCGCAAACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A118HYA4

Antitoxin

Source ID Structure
AlphaFold DB A0A118MA44

References