Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2619990..2621229 Replicon chromosome
Accession NZ_CP013444
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B4Q289
Locus tag WT26_RS31500 Protein ID WP_069274769.1
Coordinates 2620648..2621229 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B4Q2E3
Locus tag WT26_RS31495 Protein ID WP_069274768.1
Coordinates 2619990..2620547 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS31470 2615207..2615929 - 723 WP_069274766.1 hypothetical protein -
WT26_RS37835 2615928..2616161 + 234 WP_155123272.1 hypothetical protein -
WT26_RS31480 2616627..2617376 - 750 WP_155123273.1 hypothetical protein -
WT26_RS36800 2617611..2618089 + 479 Protein_2300 isochorismatase family protein -
WT26_RS31485 2618253..2618669 - 417 WP_045563786.1 hypothetical protein -
WT26_RS31490 2619002..2619733 - 732 WP_069274767.1 ribonuclease T2 -
WT26_RS31495 2619990..2620547 + 558 WP_069274768.1 helix-turn-helix domain-containing protein Antitoxin
WT26_RS31500 2620648..2621229 + 582 WP_069274769.1 HD domain-containing protein Toxin
WT26_RS31505 2621384..2622574 + 1191 WP_069274770.1 macrolide transporter subunit MacA -
WT26_RS31510 2622577..2624616 + 2040 WP_069274771.1 MacB family efflux pump subunit -
WT26_RS31515 2624622..2626007 + 1386 WP_069274772.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21295.98 Da        Isoelectric Point: 5.2986

>T58684 WP_069274769.1 NZ_CP013444:2620648-2621229 [Burkholderia cepacia]
MTPDTIHARLAFLREAERLKDVLRSGYTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKRAHERDDLLTLTASLDPARRDEIVALWDEYDAAASPEAKAVKALDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGRHA

Download         Length: 582 bp

>T58684 NZ_CP013444:2620648-2621229 [Burkholderia cepacia]
ATGACTCCCGACACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCTA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAACACAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCG
GCGATCGAACAGGCCGCGCACCCCGACAAGCGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGATCC
CGCGCGGCGCGACGAAATCGTCGCACTGTGGGATGAATACGACGCGGCCGCGTCGCCCGAAGCGAAGGCCGTCAAGGCGC
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAT
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGGGCGGGCGGCACGCGTGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20356.44 Da        Isoelectric Point: 8.9470

>AT58684 WP_069274768.1 NZ_CP013444:2619990-2620547 [Burkholderia cepacia]
MTDSPLQTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERATAERLLAARLDSAGDHALARLICD
HPGRMHLVCDLTHRLLACSSLRAAEFAKPLPTMLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFETGANASRVVP
IRGSMCRWTRMTLSDGTAARLVETL

Download         Length: 558 bp

>AT58684 NZ_CP013444:2619990-2620547 [Burkholderia cepacia]
ATGACCGACTCGCCGCTTCAAACGCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAACTGTTCGGCGTGGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCATCTGCGAC
CATCCCGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGGCTGCTGGCGTGCTCGTCGTTGCGCGCCGCCGAGTTCGC
GAAACCGCTGCCGACGATGCTCGGCACGTCGCTGTGGCGCTACGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGAGACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCATGTGCCGGTGGACACGGATGACGTTGTCGGACGGGACGGCCGCGCGGCTCGTGGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4Q289

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4Q2E3

References