Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1281587..1283337 Replicon chromosome
Accession NZ_CP013444
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4PZR7
Locus tag WT26_RS25980 Protein ID WP_069274251.1
Coordinates 1281587..1282483 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A104A2A2
Locus tag WT26_RS25985 Protein ID WP_059522424.1
Coordinates 1282480..1283337 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS25950 1276951..1278030 - 1080 WP_069274250.1 porin -
WT26_RS25955 1278483..1278800 + 318 WP_021161517.1 non-heme iron oxygenase ferredoxin subunit -
WT26_RS25960 1278802..1279113 + 312 WP_011354711.1 hypothetical protein -
WT26_RS25965 1279174..1280244 + 1071 WP_059522421.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WT26_RS25970 1280237..1281007 + 771 WP_059668082.1 SDR family oxidoreductase -
WT26_RS25975 1281041..1281568 + 528 WP_034180369.1 cupin domain-containing protein -
WT26_RS25980 1281587..1282483 + 897 WP_069274251.1 alpha/beta fold hydrolase Toxin
WT26_RS25985 1282480..1283337 + 858 WP_059522424.1 IclR family transcriptional regulator Antitoxin
WT26_RS25990 1283417..1284214 + 798 WP_059522425.1 SDR family oxidoreductase -
WT26_RS25995 1284207..1285874 + 1668 WP_069274252.1 thiamine pyrophosphate-binding protein -
WT26_RS26000 1285867..1286694 + 828 WP_059522427.1 aspartate dehydrogenase -
WT26_RS26005 1286717..1288207 + 1491 WP_069274253.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30570.84 Da        Isoelectric Point: 8.0619

>T58681 WP_069274251.1 NZ_CP013444:1281587-1282483 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANDEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA

Download         Length: 897 bp

>T58681 NZ_CP013444:1281587-1282483 [Burkholderia cepacia]
ATGAGTGTCATCGACAAGCGTGAGCGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTTCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCAGCGTTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGTGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGCCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTTGCCGAGCAACGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGACGAGGCAAAGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGTTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGTCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGTTATGTCGAGGCTCCGGCCGTCTATTCCGCCCTGATCGACGCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31448.99 Da        Isoelectric Point: 6.5067

>AT58681 WP_059522424.1 NZ_CP013444:1282480-1283337 [Burkholderia cepacia]
MNEPLQRPEPDNEKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLK

Download         Length: 858 bp

>AT58681 NZ_CP013444:1282480-1283337 [Burkholderia cepacia]
ATGAACGAACCGCTGCAACGACCCGAACCCGACAACGAAAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCCGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTTCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTCAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTTTATCCGGAGGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCACTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCGGAAATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTACAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4PZR7

Antitoxin

Source ID Structure
AlphaFold DB A0A104A2A2

References