Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 774907..775527 Replicon chromosome
Accession NZ_CP013444
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name relE Uniprot ID A0A1B4PYL7
Locus tag WT26_RS23820 Protein ID WP_069274089.1
Coordinates 775210..775527 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2GAF3
Locus tag WT26_RS23815 Protein ID WP_021157290.1
Coordinates 774907..775206 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS23790 770152..771423 + 1272 WP_059521940.1 Rieske 2Fe-2S domain-containing protein -
WT26_RS23795 771441..771926 + 486 WP_059521536.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WT26_RS23800 771946..772272 + 327 WP_006479527.1 non-heme iron oxygenase ferredoxin subunit -
WT26_RS23805 772262..773482 + 1221 WP_069274087.1 FAD-dependent oxidoreductase -
WT26_RS23810 773572..774858 + 1287 WP_069274088.1 DUF445 domain-containing protein -
WT26_RS23815 774907..775206 - 300 WP_021157290.1 putative addiction module antidote protein Antitoxin
WT26_RS23820 775210..775527 - 318 WP_069274089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WT26_RS23825 775940..777580 + 1641 WP_059665687.1 acetolactate synthase large subunit -
WT26_RS23830 777610..779043 + 1434 WP_069274090.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-91)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11996.77 Da        Isoelectric Point: 8.9480

>T58680 WP_069274089.1 NZ_CP013444:c775527-775210 [Burkholderia cepacia]
MPYSPPVFTIRTTEFFDAWFDALQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQADIRAAHAMLAHLDME

Download         Length: 318 bp

>T58680 NZ_CP013444:c775527-775210 [Burkholderia cepacia]
ATGCCCTACAGTCCTCCTGTATTCACCATCCGAACCACCGAGTTCTTCGACGCCTGGTTCGACGCGCTGCAGGATCGCGT
CGCGAAGCGACGCATCCAGGCACGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCAGGCTCGCCGG
TCGTCGAAATGCGGATCGACCACGGCCCAGGTTATCGCGTCTACTACGTGCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGCGGCGATAAATCGACGCAACAGGCCGACATACGCGCCGCGCACGCGATGCTCGCGCACCTCGACATGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10633.01 Da        Isoelectric Point: 6.3217

>AT58680 WP_021157290.1 NZ_CP013444:c775206-774907 [Burkholderia cepacia]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT58680 NZ_CP013444:c775206-774907 [Burkholderia cepacia]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGAAGACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCACGCGGCATGTCTC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACC
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4PYL7

Antitoxin

Source ID Structure
AlphaFold DB U2GAF3

References