Detailed information of TA system TA058678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1794568..1795244
• Replicon: chromosome
• Accession: NZ_CP013443
• Organism: Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: WT26_RS11610
• Protein ID: WP_081333727.1
• Coordinates: 1794828..1795244 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A1B4PRT9
• Locus tag: WT26_RS11605
• Protein ID: WP_069272922.1
• Coordinates: 1794568..1794831 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WT26_RS11590	1790177..1792399	+	2223	WP_069272919.1	TonB-dependent siderophore receptor	-
WT26_RS11595	1792485..1793342	+	858	WP_069272920.1	N(5)-hydroxyornithine transformylase PvdF	-
WT26_RS11600	1793342..1794358	+	1017	WP_069272921.1	acetyltransferase	-
WT26_RS11605	1794568..1794831	+	264	WP_069272922.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WT26_RS11610	1794828..1795244	+	417	WP_081333727.1	PIN domain-containing protein	Toxin
WT26_RS11615	1795386..1796549	+	1164	WP_059526154.1	amidohydrolase	-
WT26_RS11620	1796807..1798111	-	1305	WP_069272923.1	cobyrinate a,c-diamide synthase	-
WT26_RS11625	1798114..1798716	-	603	WP_069272924.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
WT26_RS11630	1798753..1799130	-	378	WP_059664042.1	cobalamin biosynthesis protein	-
WT26_RS11635	1799127..1799878	-	752	Protein_1662	uroporphyrinogen-III C-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14669.68 Da
• Isoelectric Point: 6.8608

>T58678 WP_081333727.1 NZ_CP013443:1794828-1795244 [Burkholderia cepacia]
VTTLYMLDTNVCSFIMRERPPAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAVAAGAVLVTHNTREFGRVDGLSFEDWAD

Nucleotide

• Length: 417 bp

>T58678 NZ_CP013443:1794828-1795244 [Burkholderia cepacia]
GTGACCACGCTCTACATGCTCGATACGAACGTCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGCAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCACAGCACCGGATCGTCGTGTCGGCCATCACCTATGCCGAAATGCGGTTCGGTGCCGTCGGCA
GGAAGGCGTCACCGAAGCACGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGCGCCGATCTCGCCGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGGTCGCGGCCGGTGCGGTGCTGGTGACCCACAACACGCGCGAATTCGGCCGCGTCGACGGGTTGTCGTTCG
AGGATTGGGCCGATTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9780.97 Da
• Isoelectric Point: 4.5098

>AT58678 WP_069272922.1 NZ_CP013443:1794568-1794831 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSLAHEPLADADFLAERPAVIESGRFDLSGPDD
AQTESGQ

Nucleotide

• Length: 264 bp

>AT58678 NZ_CP013443:1794568-1794831 [Burkholderia cepacia]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGAGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGCTGCTGCTGCGGCCGGTGCGGCCCACGTGGACGTCGCTCGCGCACGAGC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCCCCGACGAT
GCGCAAACGGAGTCCGGCCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4PRT9