Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 174747..175384 Replicon chromosome
Accession NZ_CP013443
Organism Burkholderia cepacia strain MSMB1184WGS

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B4PMX0
Locus tag WT26_RS04050 Protein ID WP_069272244.1
Coordinates 174983..175384 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1B4PMX6
Locus tag WT26_RS04045 Protein ID WP_069272243.1
Coordinates 174747..174983 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WT26_RS04025 170740..171789 - 1050 WP_069272241.1 ADP-heptose--LPS heptosyltransferase -
WT26_RS04030 171806..173509 - 1704 WP_069272242.1 thiamine pyrophosphate-binding protein -
WT26_RS04035 173778..174236 + 459 WP_059983870.1 hypothetical protein -
WT26_RS04040 174233..174541 + 309 WP_069269772.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
WT26_RS04045 174747..174983 + 237 WP_069272243.1 AbrB family transcriptional regulator Antitoxin
WT26_RS04050 174983..175384 + 402 WP_069272244.1 type II toxin-antitoxin system VapC family toxin Toxin
WT26_RS04055 175429..176817 - 1389 WP_059528035.1 L-serine ammonia-lyase -
WT26_RS04060 176848..177984 - 1137 WP_059528335.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15029.10 Da        Isoelectric Point: 4.7380

>T58675 WP_069272244.1 NZ_CP013443:174983-175384 [Burkholderia cepacia]
MARYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAVCANPDRERRNLAALIEDIPVAPFDVAAARA
YGPVREATRERKNDQLDKLIAAHAVSLDVVLVTNNERDFASYPGVRLENWLND

Download         Length: 402 bp

>T58675 NZ_CP013443:174983-175384 [Burkholderia cepacia]
ATGGCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAATCAGCCGGAACAGGTCGCGAGACGATTTGC
CCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATCACCTATGCCGAGCTCGAGTATGGTGTCGCGGTCTGCGCGAATC
CTGATCGCGAGCGCCGAAATCTCGCGGCGCTGATCGAGGACATTCCCGTCGCCCCGTTCGATGTGGCGGCGGCGCGGGCC
TACGGGCCGGTGCGGGAGGCAACGCGGGAGCGCAAGAATGACCAGCTGGACAAACTGATCGCCGCCCATGCGGTGTCGCT
CGACGTCGTGCTCGTGACCAACAACGAGCGGGATTTCGCGAGCTACCCGGGCGTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8880.94 Da        Isoelectric Point: 5.7252

>AT58675 WP_069272243.1 NZ_CP013443:174747-174983 [Burkholderia cepacia]
MHTTRAFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLEKFAKFGPDFMAEGRGDHEQADREGL

Download         Length: 237 bp

>AT58675 NZ_CP013443:174747-174983 [Burkholderia cepacia]
ATGCATACCACCCGAGCGTTCAGGAACGGCAACTCACAGGCCGTACGGATTCCGGCGGATCTTGCTTACGAGCGCAGCGA
CATCGAGCTCGAAATCGAGCGAGTGGGCGATGAAATTCGCATTCGACCTGCTCGGCGGCCGTTGACGGGTGTGCTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGACCGCGAGGGCTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4PMX0

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4PMX6

References