Detailed information of TA system TA058672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 242361..243322
• Replicon: chromosome
• Accession: NZ_CP013441
• Organism: Burkholderia vietnamiensis strain HI2297

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A1B4LHJ3
• Locus tag: WK31_RS25630
• Protein ID: WP_011880200.1
• Coordinates: 242789..243322 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A1B4LHE0
• Locus tag: WK31_RS25625
• Protein ID: WP_011880199.1
• Coordinates: 242361..242792 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK31_RS25600	238017..238424	-	408	WP_011880193.1	DUF934 domain-containing protein	-
WK31_RS25605	238421..240211	-	1791	WP_011880194.1	nitrite/sulfite reductase	-
WK31_RS30925	240345..240491	-	147	Protein_264	transposase	-
WK31_RS25615	241288..241515	+	228	WP_043292778.1	hypothetical protein	-
WK31_RS25620	241512..241946	+	435	WP_011880197.1	PIN domain-containing protein	-
WK31_RS25625	242361..242792	+	432	WP_011880199.1	hypothetical protein	Antitoxin
WK31_RS25630	242789..243322	+	534	WP_011880200.1	RES family NAD+ phosphorylase	Toxin
WK31_RS25635	243616..245313	-	1698	WP_046424735.1	tyrosine-type recombinase/integrase	-
WK31_RS25640	245410..245814	-	405	WP_126221107.1	hypothetical protein	-
WK31_RS25645	245941..247374	-	1434	WP_126221193.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	238017..307654	69637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-168)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 19147.77 Da
• Isoelectric Point: 5.1857

>T58672 WP_011880200.1 NZ_CP013441:242789-243322 [Burkholderia vietnamiensis]
MILKPLQDIIAYRMHQPKWAVAPTSGAGAAKAGGRANRVGTPALYLALEVATAVAEYQQLSPLLPPGTLVSYRVTAAPVV
DFTAGFRGDHWSPLWESFFCDWRRDWFNKRIEPPSWVLGDEVIAAGAKGILFSSTQAAGGTNLVLFVDQLDNTDRLEVID
PAGALPRDQASWGESPA

Nucleotide

• Length: 534 bp

>T58672 NZ_CP013441:242789-243322 [Burkholderia vietnamiensis]
ATGATCCTCAAGCCACTGCAGGACATCATCGCGTACCGGATGCACCAGCCCAAATGGGCGGTCGCGCCCACCAGTGGCGC
CGGGGCAGCGAAGGCAGGCGGGCGGGCGAACCGGGTCGGCACGCCGGCTTTGTACCTAGCCCTCGAAGTGGCTACCGCGG
TGGCCGAGTATCAGCAGCTGTCGCCGCTGCTACCGCCTGGCACGCTCGTGAGCTATCGCGTGACGGCCGCGCCCGTCGTT
GATTTCACGGCGGGCTTTCGTGGTGACCACTGGTCGCCATTGTGGGAGTCGTTCTTCTGCGACTGGCGCCGTGACTGGTT
CAACAAGCGGATCGAGCCACCAAGCTGGGTGCTAGGCGATGAGGTGATTGCCGCCGGCGCCAAAGGCATCCTGTTTTCGT
CAACGCAGGCAGCCGGCGGCACGAACCTGGTGCTGTTCGTTGACCAACTGGACAACACCGATCGCCTGGAGGTCATCGAT
CCAGCGGGCGCCTTGCCGCGCGATCAGGCCTCGTGGGGCGAGTCTCCCGCTTGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15299.19 Da
• Isoelectric Point: 5.6277

>AT58672 WP_011880199.1 NZ_CP013441:242361-242792 [Burkholderia vietnamiensis]
MNTLATPSPAASAATPTGAAPVSFEAFLSSLREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPESASVQHF
LREAIRVIRAATDLSGDVYRALFWYRNEPLAVFDYQTAETLVSAGRAEDVLRYIVSLEAGAAG

Nucleotide

• Length: 432 bp

>AT58672 NZ_CP013441:242361-242792 [Burkholderia vietnamiensis]
ATGAACACCCTCGCGACCCCCAGCCCAGCGGCGTCTGCGGCGACGCCCACCGGTGCGGCACCCGTCAGCTTCGAGGCCTT
TCTCAGCTCGCTACGGGAACCCGACACGGCAGCACCCGTGCTGTCGGCACGACGCTATGTGGCGGCCCTGAACATCGATC
TGCAGACGCTGGCCGACCAGGCGCATGTTCACCGAAACACCGTGGCGCGAGCCCCGGAGTCGGCATCGGTTCAGCACTTC
CTGCGCGAAGCGATCCGCGTGATTCGCGCCGCGACCGACCTGTCCGGTGACGTGTACCGCGCGTTGTTCTGGTACCGCAA
CGAGCCGCTGGCGGTGTTCGATTACCAGACAGCCGAAACGCTGGTTTCCGCCGGCCGGGCCGAGGACGTGCTGCGCTACA
TCGTGTCGCTGGAAGCGGGCGCGGCCGGATGA

Structures

Toxin

• AlphaFold DB: A0A1B4LHJ3

Antitoxin

• AlphaFold DB: A0A1B4LHE0