Detailed information of TA system TA058671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 241288..241946
• Replicon: chromosome
• Accession: NZ_CP013441
• Organism: Burkholderia vietnamiensis strain HI2297

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WK31_RS25620
• Protein ID: WP_011880197.1
• Coordinates: 241512..241946 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B4LJE8
• Locus tag: WK31_RS25615
• Protein ID: WP_043292778.1
• Coordinates: 241288..241515 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK31_RS30920	237123..237831	-	709	Protein_261	cupin domain-containing protein	-
WK31_RS25600	238017..238424	-	408	WP_011880193.1	DUF934 domain-containing protein	-
WK31_RS25605	238421..240211	-	1791	WP_011880194.1	nitrite/sulfite reductase	-
WK31_RS30925	240345..240491	-	147	Protein_264	transposase	-
WK31_RS25615	241288..241515	+	228	WP_043292778.1	hypothetical protein	Antitoxin
WK31_RS25620	241512..241946	+	435	WP_011880197.1	PIN domain-containing protein	Toxin
WK31_RS25625	242361..242792	+	432	WP_011880199.1	hypothetical protein	-
WK31_RS25630	242789..243322	+	534	WP_011880200.1	RES family NAD+ phosphorylase	-
WK31_RS25635	243616..245313	-	1698	WP_046424735.1	tyrosine-type recombinase/integrase	-
WK31_RS25640	245410..245814	-	405	WP_126221107.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	238017..307654	69637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (3-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15721.10 Da
• Isoelectric Point: 7.2342

>T58671 WP_011880197.1 NZ_CP013441:241512-241946 [Burkholderia vietnamiensis]
VITYLLDVNVLIALLDPAHVQHEPAHAWFGRVGHSAWATCPLTENGVLRIIGNPKYPNTMVSPASVAPLVVQLRSHAGHT
FWSDDVSLLDEKHVDATRLLSSAQLTDTYLLALARAHKGKLATFDRRLVVDAVPNGGKHLELIP

Nucleotide

• Length: 435 bp

>T58671 NZ_CP013441:241512-241946 [Burkholderia vietnamiensis]
GTGATTACCTACCTTCTCGACGTCAACGTACTCATTGCTTTGCTCGACCCGGCACACGTTCAACACGAGCCGGCGCATGC
GTGGTTTGGCCGGGTAGGCCATTCCGCATGGGCCACGTGCCCGCTCACCGAGAACGGCGTGCTTCGAATTATCGGCAATC
CGAAATACCCGAATACGATGGTCTCTCCTGCATCCGTTGCACCGCTTGTTGTGCAACTGCGGTCCCATGCTGGGCACACA
TTCTGGTCGGACGATGTGAGCCTGCTCGACGAAAAACACGTCGACGCCACCCGTTTACTGTCCTCCGCTCAACTGACCGA
CACTTACCTCCTCGCGCTCGCTCGCGCACACAAAGGCAAGTTGGCGACCTTCGATCGCCGCTTGGTCGTCGACGCGGTTC
CGAACGGCGGGAAGCATCTTGAACTGATTCCTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8080.14 Da
• Isoelectric Point: 8.9793

>AT58671 WP_043292778.1 NZ_CP013441:241288-241515 [Burkholderia vietnamiensis]
MRTTIDIDDDVLAFARERAKPGTSIGKVISDLARAALQRGTTNQSSRNGLPLMPVSATARPVTLDTVNQLRDDSL

Nucleotide

• Length: 228 bp

>AT58671 NZ_CP013441:241288-241515 [Burkholderia vietnamiensis]
ATGCGTACCACTATTGATATCGACGACGACGTCCTTGCCTTCGCGCGGGAGCGTGCAAAGCCCGGCACGAGTATCGGGAA
GGTCATTTCTGACCTCGCCCGTGCGGCCCTGCAGCGCGGAACAACGAACCAGTCGAGCCGAAACGGCTTGCCGTTGATGC
CGGTTTCCGCGACCGCCCGTCCGGTCACCCTTGATACCGTTAATCAACTTCGCGACGACTCGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4LJE8