Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1757385..1758026 Replicon chromosome
Accession NZ_CP013440
Organism Burkholderia vietnamiensis strain HI2297

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag WK31_RS22420 Protein ID WP_060091795.1
Coordinates 1757385..1757723 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag WK31_RS22425 Protein ID WP_011881499.1
Coordinates 1757727..1758026 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WK31_RS22410 1753926..1755359 - 1434 WP_011881502.1 aldehyde dehydrogenase family protein -
WK31_RS22415 1755388..1757028 - 1641 WP_059463465.1 acetolactate synthase large subunit -
WK31_RS22420 1757385..1757723 + 339 WP_060091795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WK31_RS22425 1757727..1758026 + 300 WP_011881499.1 putative addiction module antidote protein Antitoxin
WK31_RS22430 1758118..1759404 - 1287 WP_014724584.1 DUF445 domain-containing protein -
WK31_RS22435 1759593..1760813 - 1221 WP_059462396.1 FAD-dependent oxidoreductase -
WK31_RS22440 1760803..1761129 - 327 WP_011881496.1 non-heme iron oxygenase ferredoxin subunit -
WK31_RS22445 1761156..1761641 - 486 WP_034194948.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
WK31_RS22450 1761659..1762930 - 1272 WP_014724582.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-98)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12566.32 Da        Isoelectric Point: 9.5939

>T58670 WP_060091795.1 NZ_CP013440:1757385-1757723 [Burkholderia vietnamiensis]
MVDISSNVPYSAPTSSIRTTEVFDTWFAGLQDRVARRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRA
TIWVILLCGGDKSTQQADIRAAHAMLGRLDLE

Download         Length: 339 bp

>T58670 NZ_CP013440:1757385-1757723 [Burkholderia vietnamiensis]
ATGGTTGACATATCGAGTAACGTGCCTTACAGTGCTCCGACGTCCAGCATCAGAACGACCGAAGTCTTCGACACATGGTT
CGCCGGTCTGCAGGATCGCGTCGCACGGCGGCGTATCCAGGCCCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAGTCGGCCGGCTCCCCGGTCGTCGAGATGCGTATCGACCACGGCCCCGGCTATCGCGTCTACTACGTCAGGCGCGCG
ACGATCTGGGTGATCCTGCTCTGCGGCGGCGACAAGTCGACGCAACAGGCAGACATTCGCGCCGCGCACGCAATGCTCGG
GCGGCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10548.87 Da        Isoelectric Point: 6.0633

>AT58670 WP_011881499.1 NZ_CP013440:1757727-1758026 [Burkholderia vietnamiensis]
MDKISTRPWDSAAHLETDDDIADYFDACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKARA

Download         Length: 300 bp

>AT58670 NZ_CP013440:1757727-1758026 [Burkholderia vietnamiensis]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGCCCACCTCGAAACCGACGACGACATCGCCGACTATTTCGACGC
ATGTCTGCAGGAAGGCGGCGACGACCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGCGCGCGCGGCATGTCGC
AGGTCGCCCGCGACGCCGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACC
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References