Detailed information of TA system TA058669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 803524..804163
• Replicon: chromosome
• Accession: NZ_CP013439
• Organism: Burkholderia vietnamiensis strain HI2297

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WK31_RS03630
• Protein ID: WP_059894711.1
• Coordinates: 803744..804163 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A132DHM6
• Locus tag: WK31_RS03625
• Protein ID: WP_011883461.1
• Coordinates: 803524..803757 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WK31_RS03615	800093..802456	+	2364	WP_011883458.1	xanthine dehydrogenase molybdopterin binding subunit	-
WK31_RS03620	802544..803197	+	654	WP_069246148.1	xanthine dehydrogenase accessory protein XdhC	-
WK31_RS03625	803524..803757	+	234	WP_011883461.1	DNA-binding protein	Antitoxin
WK31_RS03630	803744..804163	+	420	WP_059894711.1	type II toxin-antitoxin system VapC family toxin	Toxin
WK31_RS03635	804293..804694	+	402	WP_046426267.1	polyketide cyclase	-
WK31_RS03640	804735..805679	-	945	WP_069246149.1	LysR family transcriptional regulator	-
WK31_RS03645	805749..806387	-	639	WP_011883469.1	2-hydroxychromene-2-carboxylate isomerase	-
WK31_RS03650	806482..807915	-	1434	WP_011883471.1	ABC transporter substrate-binding protein	-
WK31_RS03655	808384..808749	+	366	WP_059567237.1	BON domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15635.82 Da
• Isoelectric Point: 6.0999

>T58669 WP_059894711.1 NZ_CP013439:803744-804163 [Burkholderia vietnamiensis]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LGVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Nucleotide

• Length: 420 bp

>T58669 NZ_CP013439:803744-804163 [Burkholderia vietnamiensis]
ATGTTTTTGGTTGATACCAACGTCATCAGCGAAGTACGGAAGCGGGAGCGAGCAGATAAAGGTGTGATGGCGTTTTTCCG
CAAGGCCGCGCAGGACGATGCCGATCTGTACCTTTCCGTGGTGACGGTTGGCGAACTGCGGCGCGGTGTGGAAATCATCC
GTCACCGTGGCGACAAGTCCCAGGCGACGCGCCTTGAAAACTGGCTCGATGGCGTACTTCGGGAGTTTGCGTCGAACATT
CTGGGGGTGGACGAAGAGATCGGGCAGTTGTGGGGACGCCTGCGCGTCCCGCATCCCGAGCACTCGCTCGACAAGTTGAT
CGCGGCAACGGCGTTGATCCACGACCTGATCGTCGTGACGCGGAACGTCGATGATTTCGCCGGAACGGGCGCACGCGTTC
TGAACCCATTCGAAAGCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8379.44 Da
• Isoelectric Point: 5.0644

>AT58669 WP_011883461.1 NZ_CP013439:803524-803757 [Burkholderia vietnamiensis]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Nucleotide

• Length: 234 bp

>AT58669 NZ_CP013439:803524-803757 [Burkholderia vietnamiensis]
ATGGCAACTCTTCTGGTGAGAAATGTGGACGAGGAACTCGTCCAAAGCCTGCGCGAGCGGGCCGCAGCCAACGGGCGCAG
TGCGGAGGCCGAGCATCGAGAGATCCTGGCAAAGGCGCTGCGCGCGCCGCAGCGCAAGACGTTCGCGCAGGTGTTGATGA
GTATCCCGAACGTCGGAACCGATGCCGATTTTGCGCGCGTGGATGACGGCGAGGCAGCGAATGTTTTTGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A132DHM6